Kuhn Emmanuelle, Lombès Marc
Univ Paris-Sud, Faculté de Médecine Paris-Sud, UMR-S693, Le Kremlin-Bicêtre, F-94276, France.
Horm Mol Biol Clin Investig. 2013 Sep;15(2):59-69. doi: 10.1515/hmbci-2013-0033.
Numerous studies have demonstrated the interaction that exists between adipocyte differentiation, energy balance and factors involved in fluid and electrolyte homeostasis, such as the renin-angiotensin-aldosterone system. More specifically, a potential impact of aldosterone on the function of several organs implicated in the control of energy homeostasis, such as adipose tissue, liver, skeletal muscle or pancreas, has been recently described. In addition, the mineralocorticoid receptor (MR, NR3C2), a transcription factor, was shown to play a crucial role on white and brown adipocyte differentiation and function, mediating the effects of both mineralocorticoid and glucocorticoid hormones on adipose tissues. Transgenic mouse models as well as pharmacological inactivation of MR signaling provided compelling evidence that MR is an important control point for energy homeostasis. Herein, we review recent findings on the involvement of aldosterone but also of MR on energy metabolism and discuss the therapeutic potential of manipulating MR signaling for the management of metabolic disorders in humans.
众多研究已证实脂肪细胞分化、能量平衡与参与体液和电解质稳态的因素（如肾素-血管紧张素-醛固酮系统）之间存在相互作用。更具体地说，最近有研究描述了醛固酮对参与能量稳态控制的多个器官（如脂肪组织、肝脏、骨骼肌或胰腺）功能的潜在影响。此外，作为一种转录因子的盐皮质激素受体（MR，NR3C2），在白色和棕色脂肪细胞的分化及功能中发挥着关键作用，介导盐皮质激素和糖皮质激素对脂肪组织的作用。转基因小鼠模型以及MR信号通路的药理学失活提供了令人信服的证据，表明MR是能量稳态的一个重要控制点。在此，我们综述了关于醛固酮以及MR参与能量代谢的最新研究结果，并讨论了通过调控MR信号通路来治疗人类代谢紊乱的潜在可能性。
