用于角膜炎-角膜胶原交联的加速光活化发色团作为早期真菌性角膜炎的一线和唯一治疗方法。
Accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking as a first-line and sole treatment in early fungal keratitis.
作者信息
Tabibian David, Richoz Olivier, Riat Arnaud, Schrenzel Jacques, Hafezi Farhad
出版信息
J Refract Surg. 2014 Dec;30(12):855-7. doi: 10.3928/1081597X-20141113-06.
PURPOSE
To report the use of accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL) as a first-line treatment in a patient with an atypical fungal keratitis.
METHODS
Case report and literature review.
RESULTS
A patient who presented with a painful peripheral corneal infiltrate underwent PACK-CXL with a local limited abrasion and accelerated ultraviolet-A irradiation at 365 μm and 9 mW/cm² for 10 minutes. Cultures grew Aureobasidium pullulans. The corneal epithelium closed completely within 3 days and the infiltrate was completely eradicated without administration of antibiotics.
CONCLUSIONS
Accelerated PACK-CXL was successfully used as a first-line and sole treatment in a case of early fungal keratitis caused by Aureobasidium pullulans. Further characterization of the antifungal effect of PACK-CXL is needed in prospective studies.
目的
报告在一名非典型真菌性角膜炎患者中，使用加速光活化发色团进行角膜胶原交联治疗角膜炎（PACK-CXL）作为一线治疗方法的情况。
方法
病例报告及文献综述。
结果
一名出现周边角膜疼痛性浸润的患者接受了PACK-CXL治疗，伴有局部有限擦伤，并在365μm波长、9mW/cm²强度下进行加速紫外线A照射10分钟。培养结果显示为出芽短梗霉。角膜上皮在3天内完全愈合，浸润灶在未使用抗生素的情况下被完全清除。
结论
在一例由出芽短梗霉引起的早期真菌性角膜炎病例中，加速PACK-CXL成功用作一线且唯一的治疗方法。前瞻性研究需要进一步明确PACK-CXL的抗真菌作用特征。
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