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微创二尖瓣手术期间经皮上腔静脉引流:一项随机交叉研究。

Percutaneous superior vena cava drainage during minimally invasive mitral valve surgery: a randomized, crossover study.

作者信息

Bainbridge Daniel T, Chu Michael W A, Kiaii Bob, Cleland Andrew, Murkin John

机构信息

Department of Anesthesiology and Perioperative Medicine, University of Western Ontario, London, Ontario Canada.

Division of Cardiac Surgery, Department of Surgery, University of Western Ontario, London, Ontario Canada.

出版信息

J Cardiothorac Vasc Anesth. 2015 Feb;29(1):101-6. doi: 10.1053/j.jvca.2014.07.020. Epub 2014 Nov 7.

Abstract

OBJECTIVE

Minimally invasive techniques commonly are applied to mitral valve surgery; however, there has been little research investigating the optimal methods of cardiopulmonary bypass for the right minithoracotomy approach. Controversy exists as to whether a percutaneous superior vena cava drainage cannula (PSVC) is necessary during these operations. The authors, therefore, sought to determine the effect of using a percutaneous superior vena cava catheter on brain near-infrared spectroscopy, blood lactate levels, hemodynamics and surgical parameters.

DESIGN

Randomized, blinded, crossover trial.

SETTING

Tertiary care university hospital.

PARTICIPANTS

Patients undergoing minimally invasive mitral valve surgery via a right minithoracotomy.

INTERVENTIONS

Twenty minutes of either clamped or unclamped percutaneous superior vena cava neck catheter drainage, during mitral valve repair.

MEASUREMENT AND MAIN RESULTS

For the primary outcome of brain near-infrared spectroscopy, there were no differences between the two groups (percutaneous superior vena cava clamped 55.0%±11.6% versus unclamped 56.1%±10.2%) (p = 0.283). For the secondary outcomes pH (clamped 7.35±0.05 versus unclamped 7.37±0.05 p = 0.015), surgical score (clamped 1.96±1.14 versus unclamped 1.22±0.51 p = 0.002) and CVP (clamped 11.6 mmHg±4.8 mmHg versus unclamped 6.1 mmHg±6.1 mmHg p<0.001) were significantly different.

CONCLUSIONS

The use of a percutaneous superior vena cava drainage improved surgical visualization and lowered CVP, but had no effect on brain near infrared spectroscopy during minimally invasive mitral valve surgery. (ClinicalTrials.gov Identifier: NCT01166841).

摘要

目的

微创技术常用于二尖瓣手术;然而,关于右胸小切口入路二尖瓣手术的最佳体外循环方法的研究较少。对于这些手术中是否需要经皮上腔静脉引流管(PSVC)存在争议。因此,作者试图确定使用经皮上腔静脉导管对脑近红外光谱、血乳酸水平、血流动力学和手术参数的影响。

设计

随机、盲法、交叉试验。

地点

三级大学附属医院。

参与者

经右胸小切口行微创二尖瓣手术的患者。

干预措施

在二尖瓣修复期间,经皮上腔静脉颈部导管引流夹闭或不夹闭20分钟。

测量指标及主要结果

对于脑近红外光谱这一主要结局指标,两组之间无差异(经皮上腔静脉夹闭组为55.0%±11.6%,未夹闭组为56.1%±10.2%)(p = 0.283)。对于次要结局指标,pH值(夹闭组为7.35±0.05,未夹闭组为7.37±0.05,p = 0.015)、手术评分(夹闭组为1.96±1.14,未夹闭组为1.22±0.51,p = 0.002)和中心静脉压(夹闭组为11.6 mmHg±4.8 mmHg,未夹闭组为6.1 mmHg±6.1 mmHg,p<0.001)有显著差异。

结论

在微创二尖瓣手术中,使用经皮上腔静脉引流可改善手术视野并降低中心静脉压,但对脑近红外光谱无影响。(ClinicalTrials.gov标识符:NCT01166841)

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