Warner Amy E, Schaefer Melissa K, Patel Priti R, Drobeniuc Jan, Xia Guoliang, Lin Yulin, Khudyakov Yury, Vonderwahl Candace W, Miller Lisa, Thompson Nicola D
Division of Disease Control and Environmental Epidemiology, Colorado Department of Public Health and Environment, Denver, CO.
Prevention and Response Branch, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA.
Am J Infect Control. 2015 Jan;43(1):53-8. doi: 10.1016/j.ajic.2014.09.012. Epub 2014 Nov 20.
Drug diversion by health care personnel poses a risk for serious patient harm. Public health identified 2 patients diagnosed with acute hepatitis C virus (HCV) infection who shared a common link with a hospital. Further investigation implicated a drug-diverting, HCV-infected surgical technician who was subsequently employed at an ambulatory surgical center.
Patients at the 2 facilities were offered testing for HCV infection if they were potentially exposed. Serum from the surgical technician and patients testing positive for HCV but without evidence of infection before their surgical procedure was further tested to determine HCV genotype and quasi-species sequences. Parenteral medication handling practices at the 2 facilities were evaluated.
The 2 facilities notified 5970 patients of their possible exposure to HCV, 88% of whom were tested and had results reported to the state public health departments. Eighteen patients had HCV highly related to the surgical technician's virus. The surgical technician gained unauthorized access to fentanyl owing to limitations in procedures for securing controlled substances.
Public health surveillance identified an outbreak of HCV infection due to an infected health care provider engaged in diversion of injectable narcotics. The investigation highlights the value of public health surveillance in identifying HCV outbreaks and uncovering a method of drug diversion and its impacts on patients.
医护人员的药物挪用行为对患者造成严重伤害构成风险。公共卫生部门确认了2例被诊断为急性丙型肝炎病毒(HCV)感染的患者,他们与一家医院存在共同关联。进一步调查发现一名挪用药物、感染HCV的外科技术员,该技术员随后受雇于一家门诊手术中心。
如果这两家机构的患者有潜在暴露风险,会为其提供HCV感染检测。对该外科技术员以及手术前HCV检测呈阳性但无感染证据的患者的血清进行进一步检测,以确定HCV基因型和准种序列。对这两家机构的非肠道用药处理操作进行评估。
这两家机构通知了5970名患者他们可能暴露于HCV,其中88%的患者接受了检测,检测结果已报告给州公共卫生部门。18名患者的HCV与该外科技术员的病毒高度相关。由于管制药品安全程序存在缺陷,该外科技术员得以未经授权获取芬太尼。
公共卫生监测发现了一起由一名从事注射用麻醉药品挪用的受感染医护人员导致的HCV感染暴发。该调查凸显了公共卫生监测在识别HCV暴发以及揭示药物挪用方法及其对患者的影响方面的价值。