PharmaTherapeutics Clinical Research, Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA.
Computational Sciences Center of Emphasis, Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA.
Neuron. 2014 Nov 5;84(3):537-41. doi: 10.1016/j.neuron.2014.10.037.
Human genetics is a rational starting point for target identification in drug discovery, yet this approach has found little application in neuroscience. Recent large-scale analyses have begun to identify robust genetic loci for schizophrenia, providing an opportunity to derive novel drug targets. Here, we summarize a strategy for applying human genetics to neuroscience drug discovery.
人类遗传学是药物发现中目标确定的合理起点，但这种方法在神经科学中应用甚少。最近的大规模分析已经开始确定精神分裂症的稳健遗传位点，为衍生新的药物靶点提供了机会。在这里，我们总结了一种将人类遗传学应用于神经科学药物发现的策略。
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