Walker Simon R, Wagner Martin, Tangri Navdeep
Department of Medicine, Division of Nephrology, Seven Oaks General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada.
Department of Medicine, Division of Nephrology, University of Würzburg, Bavaria, Germany.
J Ren Nutr. 2014 Nov;24(6):364-70. doi: 10.1053/j.jrn.2014.09.001. Epub 2014 Oct 22.
The global prevalence of chronic kidney disease (CKD) is rising, particularly among the elderly population. Defining aging as successful or unsuccessful has become clinically relevant in the last 15 years, with an increased recognition of the frail phenotype. Frailty has been shown to be associated with CKD and poorer outcomes, such as death or dialysis. It is likely that the mechanisms of disease in CKD such as altered protein metabolism, inflammation, oxidative stress, and anemia accelerate normal aging and lead to worsening frailty in elderly patients with CKD.
慢性肾脏病（CKD）的全球患病率正在上升，尤其是在老年人群中。在过去15年里，将衰老定义为成功或不成功已具有临床相关性，人们对衰弱表型的认识有所增加。衰弱已被证明与CKD及较差的预后相关，如死亡或透析。CKD中的疾病机制，如蛋白质代谢改变、炎症、氧化应激和贫血，可能会加速正常衰老，并导致老年CKD患者的衰弱加剧。
