组织扫描对精囊侵犯的敏感性和特异性较低。

Histoscanning has low sensitivity and specificity for seminal vesicle invasion.

作者信息

Schiffmann Jonas, Beyer Burkhard, Fischer Johannes, Tennstedt Pierre, Boehm Katharina, Michl Uwe, Graefen Markus, Salomon Georg

机构信息

Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

出版信息

Urology. 2014 Nov;84(5):1168-71. doi: 10.1016/j.urology.2014.06.050. Epub 2014 Oct 24.

DOI:10.1016/j.urology.2014.06.050

PMID:25443925

Abstract

OBJECTIVE

To examine the accuracy of HistoScanning (HS) in detecting seminal vesicle (SV) invasion (SVI) within prostate cancer (PCa) patients.

METHODS

We relied on our prospective institutional database. Patients who received HS before radical prostatectomy were included in the study cohort. An experienced HS examiner retrospectively reanalyzed the HS data blinded to patient characteristics and pathologic results. The HS results for every single SV were compared with the corresponding findings from the final pathologic report after radical prostatectomy. An area under the receiver operating characteristic curve for the prediction of SVI by HS was calculated. Depending on HS signal volume cut-offs (>0, >0.2, and >0.5 mL), the sensitivity, specificity, positive predictive value, and negative predictive value for the prediction of SVI were assessed.

RESULTS

Overall, 131 patients and 262 SVs were assessable. Of those, 23 (17.5%) men had SVI, and 39 (14.9%) single SVs were infiltrated by tumor overall. The area under the receiver operating characteristic curve for predicting SVI by HS was 0.54. Depending on the HS signal volume cut-offs (>0, >0.2, and >0.5 mL), the sensitivity, specificity, positive predictive value, and negative predictive value for predicting SVI were 76.9%, 10.8%, 13.1%, and 72.7%; 61.5%, 24.2%, 12.4%, and 78.3%; and 46.2%, 50.2%, 14.0%, and 84.2%, respectively.

CONCLUSION

HS results did not allow a reliable prediction of SVI within PCa patients. Despite, the application of HS signal volume cut-offs (>0.2 and >0.5 mL), the prediction of SVI within PCa patients remained insufficient.

摘要

目的

检测组织扫描（HS）在前列腺癌（PCa）患者中检测精囊侵犯（SVI）的准确性。

方法

我们依托前瞻性机构数据库。研究队列纳入了在根治性前列腺切除术前行HS检查的患者。一名经验丰富的HS检查人员在对患者特征和病理结果不知情的情况下回顾性重新分析HS数据。将每个精囊的HS结果与根治性前列腺切除术后最终病理报告中的相应结果进行比较。计算HS预测SVI的受试者工作特征曲线下面积。根据HS信号体积截断值（>0、>0.2和>0.5 mL），评估预测SVI的敏感性、特异性、阳性预测值和阴性预测值。

结果

总体而言，131例患者和262个精囊可进行评估。其中，23例（17.5%）男性存在SVI，总体上有39个（14.9%）单个精囊被肿瘤浸润。HS预测SVI的受试者工作特征曲线下面积为0.54。根据HS信号体积截断值（>0、>0.2和>0.5 mL），预测SVI的敏感性、特异性、阳性预测值和阴性预测值分别为76.9%、10.8%、13.1%和72.7%；61.5%、24.2%、12.4%和78.3%；以及46.2%、50.2%、14.0%和84.2%。