选择性靶向促性腺激素释放激素-II神经元以阻断排卵。
Selective targeting of GnRH-II neurons to block ovulation.
作者信息
Urbanski Henryk F
机构信息
Division of Neuroscience and Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA.
出版信息
Contraception. 2015 May;91(5):423-5. doi: 10.1016/j.contraception.2014.09.010. Epub 2014 Sep 28.
Abstract
BACKGROUND
In rhesus macaques, luteinizing hormone (LH) secretion appears to be regulated by two distinct gonadotropin-releasing hormone (GnRH) neuronal populations, which can be distinguished by their unique anatomical locations and because they express different molecular forms of GnRH (GnRH-I and GnRH-II).
STUDY DESIGN
The effect of estradiol on GnRH gene expression was examined.
RESULTS
Estradiol inhibited GnRH-I neurons but stimulated GnRH-II neurons, suggesting that GnRH-II neurons play the dominant role in mediating estradiol-positive feedback and triggering the midcycle preovulatory LH surge.
CONCLUSIONS
Selective silencing of GnRH-II neurons in women could serve as a novel contraceptive, by blocking ovulation while leaving the rest of the reproductive axis relatively unperturbed.
摘要
背景
在恒河猴中，促黄体生成素（LH）的分泌似乎受两种不同的促性腺激素释放激素（GnRH）神经元群体调节，这两种群体可通过其独特的解剖位置以及它们表达不同分子形式的GnRH（GnRH-I和GnRH-II）来区分。
研究设计
检测了雌二醇对GnRH基因表达的影响。
结果
雌二醇抑制GnRH-I神经元，但刺激GnRH-II神经元，这表明GnRH-II神经元在介导雌二醇正反馈和触发周期中期排卵前LH峰中起主导作用。
结论
女性GnRH-II神经元的选择性沉默可作为一种新型避孕药，通过阻断排卵，同时使生殖轴的其余部分相对不受干扰。
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