使用当前的水痘疫苗作为活的多价疫苗载体。

Use of a current varicella vaccine as a live polyvalent vaccine vector.

作者信息

Murakami Kouki, Mori Yasuko

机构信息

Division of Clinical Virology, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan; Kanonji Institute, Seto Center, The Research Foundation for Microbial Diseases of Osaka University, 4-1-70, Seto-cho, Kanonji, Kagawa 768-0065, Japan.

Division of Clinical Virology, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

出版信息

Vaccine. 2016 Jan 4;34(2):296-298. doi: 10.1016/j.vaccine.2014.11.001. Epub 2014 Nov 11.

DOI:10.1016/j.vaccine.2014.11.001

PMID:25444800

Abstract

Varicella-zoster virus (VZV) is the causative agent of varicella and zoster. The varicella vaccine was developed to control VZV infection in children. The currently available Oka vaccine strain is the only live varicella vaccine approved by the World Health Organization. We previously cloned the complete genome of the Oka vaccine strain into a bacterial artificial chromosome vector and then successfully reconstituted the virus. We then used this system to generate a recombinant Oka vaccine virus expressing mumps virus gene(s). The new recombinant vaccine may be an effective polyvalent live vaccine that provides protection against both varicella and mumps viruses. In this review, we discussed about possibility of polyvalent live vaccine(s) using varicella vaccine based on our recent studies.

摘要

水痘带状疱疹病毒（VZV）是水痘和带状疱疹的病原体。水痘疫苗的研发旨在控制儿童的VZV感染。目前可用的Oka疫苗株是世界卫生组织批准的唯一一种活水痘疫苗。我们之前已将Oka疫苗株的完整基因组克隆到细菌人工染色体载体中，然后成功重建了该病毒。接着，我们利用该系统生成了表达腮腺炎病毒基因的重组Oka疫苗病毒。这种新型重组疫苗可能是一种有效的多价活疫苗，可同时预防水痘和腮腺炎病毒。在本综述中，我们基于近期研究探讨了使用水痘疫苗制备多价活疫苗的可能性。