哌甲酯的注意力增强作用具有年龄依赖性。
Attention enhancing effects of methylphenidate are age-dependent.
作者信息
Bhattacharya Shevon E, Shumsky Jed S, Waterhouse Barry D
机构信息
Drexel University College of Medicine, Philadelphia, PA 19129, United States.
出版信息
Exp Gerontol. 2015 Jan;61:1-7. doi: 10.1016/j.exger.2014.11.006. Epub 2014 Nov 11.
The psychostimulant methylphenidate (MPH, Ritalin®) is used to treat a variety of cognitive disorders. MPH is also popular among healthy individuals, including the elderly, for its ability to focus attention and improve concentration, but these effects have not been shown to be comparable between aged and adult subjects. Thus, we tested whether MPH would improve performance in sustained attention in both adult and aged rats. In addition, we tested the impact of visual distraction on performance in this task and the ability of MPH to mitigate the effects of distraction. Adult (6-12 months) and aged (18-22 months) male Sprague-Dawley rats were given oral MPH, and their cognitive and motor abilities were tested. Results suggest that while MPH improves task performance in adults; there is no improvement in the aged animals. These outcomes suggest that the use of MPH for cognitive enhancement in elderly individuals may be ineffective.
精神振奋剂哌醋甲酯（MPH，利他林®）用于治疗多种认知障碍。MPH在包括老年人在内的健康个体中也很受欢迎，因为它能够集中注意力并提高专注力，但尚未证明这些效果在老年受试者和成年受试者之间具有可比性。因此，我们测试了MPH是否会改善成年和老年大鼠的持续注意力表现。此外，我们测试了视觉干扰对该任务表现的影响以及MPH减轻干扰影响的能力。对成年（6 - 12个月）和老年（18 - 22个月）雄性斯普拉格-道利大鼠口服MPH，并测试它们的认知和运动能力。结果表明，虽然MPH可改善成年大鼠的任务表现，但老年动物没有改善。这些结果表明，在老年人中使用MPH进行认知增强可能无效。
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