成年人的睡眠时间与肥胖：前瞻性研究的荟萃分析

Sleep duration and obesity among adults: a meta-analysis of prospective studies.

作者信息

Wu Yili, Zhai Long, Zhang Dongfeng

机构信息

Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, China.

出版信息

Sleep Med. 2014 Dec;15(12):1456-62. doi: 10.1016/j.sleep.2014.07.018. Epub 2014 Sep 28.

DOI:10.1016/j.sleep.2014.07.018

PMID:25450058

Abstract

BACKGROUND

Results from longitudinal studies on sleep duration and incidence of obesity remain controversial.

METHODS

PubMed and Web of Science updated on 20 February 2014 were searched for eligible publications. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using a random-effects model.

RESULTS

Eleven published articles were included, involving 197,906 participants for short sleep duration and 164,016 participants for long sleep duration. Compared with the normal sleep duration, the pooled OR for obesity was 1.45 (95% CI, 1.25-1.67) for the short sleep duration overall. After removing the three studies that had strong effects on heterogeneity, the pooled OR was 1.25 (95% CI, 1.14-1.38). The positive association was consistent among all subgroups analysis except in the European group (OR, 1.45; 95% CI, 0.79-2.64). No significant association was found between long sleep duration and risk of obesity overall (OR, 1.06; 95% CI, 0.98-1.15) and in subgroup analysis.

CONCLUSION

This meta-analysis indicated that short sleep duration was significantly associated with incidence of obesity, whereas long sleep duration had no effect on future obesity among adults.

摘要

背景

关于睡眠时间与肥胖发生率的纵向研究结果仍存在争议。

方法

检索2014年2月20日更新的PubMed和科学网，查找符合条件的出版物。采用随机效应模型计算合并比值比（OR）及其95%置信区间（CI）。

结果

纳入11篇已发表文章，涉及197,906名短睡眠时间参与者和164,016名长睡眠时间参与者。总体而言，与正常睡眠时间相比，短睡眠时间的肥胖合并OR为1.45（95%CI，1.25 - 1.67）。剔除对异质性有强烈影响的三项研究后，合并OR为1.25（95%CI，1.14 - 1.38）。除欧洲组外（OR，1.45；95%CI，0.79 - 2.64），所有亚组分析中均存在正相关。总体上长睡眠时间与肥胖风险之间未发现显著关联（OR，1.06；95%CI，0.98 - 1.15），亚组分析亦是如此。