过表达的KDM5B与胶质瘤的进展相关，并通过下调p21促进胶质瘤细胞生长。
Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21.
作者信息
Dai Bin, Hu Zhiqiang, Huang Hui, Zhu Guangtong, Xiao Zhiyong, Wan Weiqing, Zhang Peng, Jia Wang, Zhang Liwei
机构信息
Department of Neurosurgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Department of Neurosurgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
出版信息
Biochem Biophys Res Commun. 2014 Nov 7;454(1):221-7. doi: 10.1016/j.bbrc.2014.10.078. Epub 2014 Oct 22.
Epigenetic alterations such as aberrant expression of histone-modifying enzymes have been implicated in tumorigenesis. Upregulation of lysine (K)-specific demethylase 5B (KDM5B) has been reported in a variety of malignant tumors. However, the impact of KDM5B in glioma remains unclear. The objective of this study was to investigate the expression and prognostic value of KDM5B in glioma. In clinical glioma samples, we found that KDM5B expression was significantly upregulated in cancer lesions compared with normal brain tissues. Kaplan-Meier analysis showed that patients with glioma and higher KDM5B expression tend to have shorter overall survival time. By silencing or overexpressing KDM5B in glioma cells, we found that KDM5B could promote cell growth both in vitro and in vivo. Moreover, we demonstrated that KDM5B promoted glioma proliferation partly via regulation of the expression of p21. Our study provided evidence that KDM5B functions as a novel tumor oncogene in glioma and may be a potential therapeutic target for glioma management.
表观遗传改变，如组蛋白修饰酶的异常表达，已被认为与肿瘤发生有关。赖氨酸（K）特异性去甲基化酶5B（KDM5B）的上调已在多种恶性肿瘤中被报道。然而，KDM5B在胶质瘤中的作用仍不清楚。本研究的目的是探讨KDM5B在胶质瘤中的表达及预后价值。在临床胶质瘤样本中，我们发现与正常脑组织相比，癌灶中KDM5B表达显著上调。Kaplan-Meier分析显示，KDM5B表达较高的胶质瘤患者总生存时间往往较短。通过在胶质瘤细胞中沉默或过表达KDM5B，我们发现KDM5B在体外和体内均可促进细胞生长。此外，我们证明KDM5B部分通过调节p21的表达促进胶质瘤增殖。我们的研究提供了证据，表明KDM5B在胶质瘤中作为一种新的肿瘤癌基因发挥作用，可能是胶质瘤治疗的潜在靶点。
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