Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands.
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands.
Psychiatry Res. 2014 Dec 30;224(3):204-10. doi: 10.1016/j.pscychresns.2014.10.007. Epub 2014 Oct 19.
The great majority of studies on repetitive transcranial magnetic stimulation (rTMS) as a therapeutic tool for auditory verbal hallucinations (AVH) have used 1-Hz stimulation with inconsistent results. Recently, it has been suggested that 20-Hz rTMS has strong therapeutic effects. It is conceivable that this 20-Hz stimulation is more effective than 1-Hz stimulation. The aim of this preliminary study is to investigate the efficacy of 20-Hz rTMS compared with 1-Hz rTMS as a treatment for AVH. Eighteen schizophrenia patients with medication-resistant AVH were randomized over two treatment groups. Each group received either 20 min of 1-Hz rTMS or 13 trains of 20-Hz rTMS daily over 1 week. After week 1, patients received a follow-up treatment once a week for 3 weeks. Stimulation location was based on individual AVH-related activation patterns identified with functional magnetic resonance imaging. Severity of AVH was monitored with the Auditory Hallucination Rating Scale (AHRS). Both groups showed a decrease in AVH after week 1 of rTMS. This decrease was significant for the 20-Hz group and the 1-Hz group. When the two treatment types were compared, no treatment type was superior. Based on these results we cannot conclude whether high frequency rTMS is more effective against AVH than is traditional 1-Hz rTMS. More research is needed to optimize stimulation parameters and to investigate potential target locations for stimulation.
大多数关于重复经颅磁刺激(rTMS)作为治疗听觉言语幻觉(AVH)的工具的研究都使用了 1Hz 的刺激,但结果不一致。最近,有研究表明 20Hz rTMS 具有很强的治疗效果。可以想象,这种 20Hz 的刺激比 1Hz 的刺激更有效。本初步研究旨在探讨 20Hz rTMS 与 1Hz rTMS 作为治疗 AVH 的疗效比较。18 名患有药物难治性 AVH 的精神分裂症患者被随机分为两组。每组患者每天接受 1Hz rTMS 治疗 20 分钟或 20Hz rTMS 治疗 13 次,为期 1 周。第 1 周后,患者每周接受一次随访治疗,持续 3 周。刺激部位基于个体功能磁共振成像识别的与 AVH 相关的激活模式。AVH 的严重程度通过听觉幻觉评定量表(AHRS)进行监测。两组患者在 rTMS 治疗 1 周后均出现 AVH 减轻。20Hz 组和 1Hz 组的下降均具有统计学意义。当比较两种治疗类型时,没有一种治疗类型更优。基于这些结果,我们无法得出高频 rTMS 是否比传统的 1Hz rTMS 更有效地治疗 AVH 的结论。需要进一步研究以优化刺激参数,并研究刺激的潜在目标部位。
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