通过网蛋白进行网络连接与锚定：中间丝功能及机械转导的关键

Networking and anchoring through plectin: a key to IF functionality and mechanotransduction.

作者信息

Wiche Gerhard, Osmanagic-Myers Selma, Castañón Maria J

机构信息

Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.

Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria; Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria.

出版信息

Curr Opin Cell Biol. 2015 Feb;32:21-9. doi: 10.1016/j.ceb.2014.10.002. Epub 2014 Oct 29.

DOI:10.1016/j.ceb.2014.10.002

PMID:25460778

Abstract

Intermediate filaments (IFs) are involved in multiple cellular processes that are essential for the maintenance of cell and tissue integrity as well as response and adaption to stress. Mainly through pathological manifestations in patients and the analysis of genetic mouse models, it became evident that cytolinker proteins of the plakin protein family are essential for many of the functions ascribed to IFs. As discussed in this review, one of them, plectin, affects the assembly properties, interaction potential, compartmentalization, and linkage properties of IFs, making it to a key player for IF functionality. The far reaching consequences of IFs not being well-connected for skin and muscular integrity, migration, and mechanotransduction are highlighted.

摘要

中间丝（IFs）参与多种细胞过程，这些过程对于维持细胞和组织的完整性以及对应激的反应和适应至关重要。主要通过对患者病理表现和基因小鼠模型的分析，很明显，丝状肌动蛋白家族的细胞连接蛋白对于许多归因于中间丝的功能至关重要。如本综述中所讨论的，其中之一，网蛋白，影响中间丝的组装特性、相互作用潜力、区室化和连接特性，使其成为中间丝功能的关键参与者。强调了中间丝连接不良对皮肤和肌肉完整性、迁移和机械转导的深远影响。