Emonet Stephane, Wuillemin Timothee, Harbarth Stephan, Wassilew Nasstasja, Cikirikcioglu Mustafa, Schrenzel Jacques, Lagier Jean-Christophe, Raoult Didier, van Delden Christian
Service of Infectious Diseases, Department of Medical Specialties, University Hospitals Geneva, Switzerland; Bacteriology laboratory, Department of Laboratories and Genetic Medicine, University Hospitals Geneva, Switzerland.
Internal Medicine Department, University Hospitals Geneva, Switzerland.
Int J Infect Dis. 2015 Jan;30:17-9. doi: 10.1016/j.ijid.2014.11.003. Epub 2014 Nov 6.
The best treatment for Tropheryma whipplei infections is controversial. We report a patient who suffered from T. whipplei aortic native valve endocarditis that relapsed despite surgery and four weeks of intravenous ceftriaxone followed by several months of oral trimethoprim/sulfamethoxazole. Cure was achieved after replacement of the prosthesis with a homograft and 18 months of oral doxycycline-hydroxychloroquine. We discuss the need for a change in treatment guidelines for T. whipplei infections.
惠普尔嗜组织菌感染的最佳治疗方法存在争议。我们报告了一名患有惠普尔嗜组织菌主动脉瓣心内膜炎的患者，尽管接受了手术并静脉注射头孢曲松四周，随后口服复方新诺明数月，但仍复发。在用同种异体移植瓣膜置换假体并口服强力霉素-羟氯喹18个月后实现了治愈。我们讨论了改变惠普尔嗜组织菌感染治疗指南的必要性。
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