Wooding F B P, Wilsher S, Benirschke K, Jones C J P, Allen W R
The Physiological Laboratory, University of Cambridge, Downing Site, Cambridge CB2 3EG, UK.
The Paul Mellon Laboratory, 'Brunswick', 18 Woodditton Road, Newmarket, Suffolk CB8 9BJ, UK.
Placenta. 2015 Jan;36(1):77-87. doi: 10.1016/j.placenta.2014.10.010. Epub 2014 Nov 5.
The trophoblast binucleate cell [BNC] is central to the structure and function of all ruminant placentas so far investigated. The Giraffidae are considered to form a separate family within the ruminant suborder.
The structure and function of two [mid and late pregnant] giraffe placentas and two term okapi placentas have been investigated immunocytochemically.
Their major characteristics: polycotyledonary epitheliochorial structure, sequential glucose transport using two transporter isoforms, expression of water transporters in the interplacentomal [IP] and placentomal [P] trophoblast and restriction of calcium transport to the IP trophoblast are similar to those of the ruminant family Bovidae. . Giraffe and okapi also show characteristic ruminant trophoblast binucleate cells (BNC) which migrate and fuse with individual uterine epithelial cells as in the cow. However, there are many fewer BNC, of limited distribution, when compared with other ruminants so far investigated. The giraffe and okapi BNC also show a different range of proteins, Pregnancy Associated Glycoproteins (PAGs) and glycans which clearly distinguish the Giraffidae from the Bovidae.
The results support a separate giraffid family derived from a common ancestry, possessing subpopulations of BNC with potentially different functions.
滋养层双核细胞[BNC]对于迄今为止所研究的所有反刍动物胎盘的结构和功能至关重要。长颈鹿科被认为在反刍亚目中形成一个独立的科。
对两个[妊娠中期和晚期]长颈鹿胎盘以及两个足月霍加狓胎盘的结构和功能进行了免疫细胞化学研究。
它们的主要特征：多子叶上皮绒毛膜结构、使用两种转运蛋白异构体进行顺序性葡萄糖转运、在胎盘间[IP]和胎盘[P]滋养层中表达水通道蛋白以及将钙转运限制在IP滋养层，这些与反刍动物牛科相似。长颈鹿和霍加狓也显示出典型的反刍动物滋养层双核细胞（BNC），它们像在牛中一样迁移并与单个子宫上皮细胞融合。然而，与迄今为止所研究的其他反刍动物相比，BNC数量少得多，分布有限。长颈鹿和霍加狓的BNC还显示出不同范围的蛋白质、妊娠相关糖蛋白（PAGs）和聚糖，这清楚地将长颈鹿科与牛科区分开来。
结果支持长颈鹿科源自共同祖先，拥有功能可能不同的BNC亚群。
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