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一种针对妇科恶性肿瘤的高剂量率阴道模具近距离放射治疗的独特方法。

A unique approach to high-dose-rate vaginal mold brachytherapy of gynecologic malignancies.

作者信息

Nilsson Sanna, Moutrie Zoë, Cheuk Robyn, Chan Philip, Lancaster Craig, Markwell Tim, Dawes Jodi, Back Phil

机构信息

Cancer Care Services, Royal Brisbane & Women's Hospital, Brisbane, Australia.

Cancer Care Services, Royal Brisbane & Women's Hospital, Brisbane, Australia.

出版信息

Brachytherapy. 2015 Mar-Apr;14(2):267-72. doi: 10.1016/j.brachy.2014.10.004. Epub 2014 Nov 18.

Abstract

PURPOSE

Patients with cervical and vaginal cancer sometimes have a less straightforward approach for choice of brachytherapy treatment owing to the tumor's location and clinical presentation. The staff at Royal Brisbane & Women's Hospital in Queensland, Australia, is trying to solve this problem by the use of an old technique in a new approach called vaginal molds. With a patient-specific vaginal mold, the appearance of the applicator and the dose distribution can be customized to provide an optimal treatment for each patient.

METHODS AND MATERIALS

The technique used at the Royal Brisbane & Women's Hospital uses a flexible two-part putty, moulded to the shape of the vagina, in which standard catheters (flexible implant tubes) are incorporated, in a pattern designed to permit a dose distribution more conformal to the target volume.

RESULTS

The presented technique is efficient and improves the accuracy of a homogeneous target cover and sparing of organs at risk for vaginal mold brachytherapy treatments at our institution.

CONCLUSION

This technique offers a customizable option when traditional cylindrical- or dome-type applicators cannot be used, or provide inadequate dose coverage. Molds to match the patient anatomy can be created quickly, while allowing flexibility in positioning of catheters to achieve the desired dose distribution.

摘要

目的

由于肿瘤的位置和临床表现,宫颈癌和阴道癌患者在选择近距离放射治疗时,治疗方法有时不那么直接。澳大利亚昆士兰州皇家布里斯班妇女医院的工作人员正试图通过一种名为阴道模具的新方法运用一种旧技术来解决这个问题。使用针对患者定制的阴道模具,可以定制施源器的外观和剂量分布,为每位患者提供最佳治疗。

方法和材料

皇家布里斯班妇女医院使用的技术是采用一种灵活的两部分油灰,将其模制成阴道形状,并在其中按照设计好的模式嵌入标准导管(柔性植入管),这种模式能使剂量分布更贴合靶区体积。

结果

所介绍的技术是有效的,提高了我院阴道模具近距离放射治疗中均匀覆盖靶区和保护危及器官的准确性。

结论

当无法使用传统的圆柱形或穹顶型施源器,或剂量覆盖不足时,该技术提供了一种可定制的选择。可以快速制作出与患者解剖结构相匹配的模具,同时在导管定位上具有灵活性,以实现所需的剂量分布。

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