Marion-Veyron Régis, Lambert Martin, Cotton Sue M, Schimmelmann Benno G, Gravier Bruno, McGorry Patrick D, Conus Philippe
Treatment and Early Intervention in Psychosis Program(TIPP), Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Clinique de Cery, 1008 Prilly, Switzerland.
Psychosis Early Detection and Intervention Centre (PEDIC), Centre for Psychosocial Medicine, Department for Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Germany.
Schizophr Res. 2015 Feb;161(2-3):163-8. doi: 10.1016/j.schres.2014.09.078. Epub 2014 Nov 20.
Previous literature suggests that early psychosis (EP) patients with a history of offending behavior (HOB) have specific clinical needs. The aims of this study were to assess: (1) the prevalence of HOB in a representative sample of EP; (2) the premorbid and baseline characteristics of patients with HOB, and (3) the potential differences in short-term outcome of such patients when compared to patients without HOB.
The Early Psychosis Prevention and Intervention Centre (EPPIC) admitted 786 EP patients between 1998 and 2000. Data were collected from patients' files using a standardized questionnaire. Data of 647 patients could be analyzed.
HOB patients (29% of the sample) were more likely to be male with lower level of premorbid functioning and education, have used illicit substances and have attempted suicide. They presented with a more complex clinical picture and had poorer 18-month outcome. Most importantly, they had a significantly longer duration of untreated psychosis.
On the basis of the high prevalence and specific features of EP patients with HOB, our study confirms a need for additional research in this domain and for the development of specific treatment strategies. Most importantly, it suggests a need for the promotion of early detection strategies among the populations of young offenders, considering that some of them may be going through the early phases of a psychotic disorder and that reduction of treatment delay and provision of well adapted interventions may have a significant impact at numerous levels in such patients.
既往文献表明,有攻击行为史(HOB)的早期精神病(EP)患者有特定的临床需求。本研究的目的是评估:(1)在具有代表性的EP样本中HOB的患病率;(2)有HOB患者的病前和基线特征;(3)与无HOB患者相比,此类患者短期结局的潜在差异。
早期精神病预防与干预中心(EPPIC)在1998年至2000年期间收治了786例EP患者。使用标准化问卷从患者档案中收集数据。647例患者的数据可供分析。
有HOB的患者(占样本的29%)更可能为男性,病前功能水平和教育程度较低,使用过非法物质且有自杀未遂史。他们呈现出更复杂的临床症状,18个月结局较差。最重要的是,他们的未治疗精神病持续时间显著更长。
基于有HOB的EP患者的高患病率和特定特征,我们的研究证实需要在该领域进行更多研究并制定特定的治疗策略。最重要的是,这表明需要在年轻罪犯群体中推广早期检测策略,因为他们中的一些人可能正处于精神病性障碍的早期阶段,减少治疗延迟并提供适当的干预措施可能会对这类患者在多个层面产生重大影响。