老年胶质母细胞瘤

Glioblastoma in the elderly.

作者信息

Chamberlain Marc C

机构信息

Department of Neurology and Neurological Surgery, University of Washington/Fred Hutchison Cancer Research Center, Seattle Cancer Care Alliance, 825 Eastlake Ave East MS G4940, Box 19023, Seattle, WA, 98109, USA,

出版信息

Cancer Treat Res. 2015;163:159-70. doi: 10.1007/978-3-319-12048-5_10.

DOI:10.1007/978-3-319-12048-5_10

PMID:25468231

Abstract

There is no generally agreed upon standard of care treatment for elderly patients (age ≥70 years) with glioblastoma (GBM). Treatment options range from supportive care only, radiation therapy (RT) only (most often given in a shortened hypofractionated schedule), temozolomide (TMZ) chemotherapy only, and the combination RT + TMZ, followed by post-RT TMZ as is the current standard of care for younger good performance patients with newly diagnosed GBM.

摘要

对于老年（年龄≥70岁）胶质母细胞瘤（GBM）患者，目前尚无普遍认可的标准治疗方案。治疗选择包括仅给予支持性治疗、仅进行放射治疗（RT）（大多采用缩短的超分割方案）、仅进行替莫唑胺（TMZ）化疗，以及RT+TMZ联合治疗，随后进行放疗后TMZ治疗，这是目前新诊断的年轻身体状况良好的GBM患者的标准治疗方案。