[Cyclic nucleotide levels in the gastric juice of patients with recurrent duodenal ulcer].

Cyclic nucleotide content in the gastric juice of patients with duodenal ulcer recurrences was studied before and after reconstructive surgery and in remote periods. The basal secretion phase was characterized by an increased cyclic nucleotide concentration in gastric juice; histamine and insulin stimulation caused decrease in their concentration. After reconstructive surgery, acid production in the basal period decreased, while cyclic adenosine monophosphate concentration increased by more than 100 per cent. The long-term period was characterized by clear intensification of cyclic adenosine monophosphate excretion under the action of histamine. It has been suggested that the release of this nucleotide from gastric mucosa cells is a subsidiary mechanism for maintenance of its necessary intracellular concentration.