将口腔都柏林念珠菌分离株短暂暴露于亚致死浓度的多烯类、唑类和氯己定后，其在丙烯酸义齿表面的体外黏附情况。
In vitro adhesion of oral Candida dubliniensis isolates to acrylic denture surfaces following brief exposure to sub-cidal concentrations of polyenes, azoles and chlorhexidine.
作者信息
Ellepola Arjuna N B, Joseph Bobby K, Altarakemah Yacoub, Samaranayake Lakshman P, Anil Sukumaran, Hashem Mohamed, Khan Zia U
机构信息
Departments of Bioclinical, Diagnostics and Restorative Sciences, Faculty of Dentistry, Kuwait University, Jabriya, Kuwait.
出版信息
Med Princ Pract. 2015;24(1):58-64. doi: 10.1159/000369019. Epub 2014 Nov 29.
OBJECTIVES
We aimed to investigate the effect of brief exposure to sub-cidal concentrations of nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate on the adhesion of oral Candida dubliniensis isolates to the surface of acrylic dentures.
METHODS
After determining the minimum inhibitory concentration of each drug, 20 oral isolates of C. dubliniensis were exposed to sub-cidal concentrations of the drugs for 1 h. The drugs were then removed by dilution, and the adhesion of the isolates to denture acrylic strips was assessed by an in vitro adhesion assay.
RESULTS
Compared to the controls, exposure to nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate suppressed the ability of C. dubliniensis isolates to adhere to acrylic denture surfaces with a reduction of 74.68, 74.27, 57.31, 44.57 and 56.53% (p < 0.001 for all drugs), respectively.
CONCLUSIONS
Brief exposure to sub-cidal concentrations of anti-mycotics suppressed the adhesion of C. dubliniensis oral isolates to acrylic denture surfaces.
目的
我们旨在研究短暂暴露于低于杀菌浓度的制霉菌素、两性霉素B、酮康唑、氟康唑和葡萄糖酸氯己定对口腔杜氏假丝酵母菌分离株黏附于丙烯酸义齿表面的影响。
方法
在确定每种药物的最低抑菌浓度后，将20株口腔杜氏假丝酵母菌分离株暴露于低于杀菌浓度的药物中1小时。然后通过稀释去除药物，并通过体外黏附试验评估分离株对义齿丙烯酸条的黏附情况。
结果
与对照组相比，暴露于制霉菌素、两性霉素B、酮康唑、氟康唑和葡萄糖酸氯己定后，杜氏假丝酵母菌分离株黏附于丙烯酸义齿表面的能力受到抑制，分别降低了74.68%、74.27%、57.31%、44.57%和56.53%（所有药物的p<0.001）。
结论
短暂暴露于低于杀菌浓度的抗真菌药物可抑制口腔杜氏假丝酵母菌分离株对丙烯酸义齿表面的黏附。
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