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[视觉接收的酶学:信号放大的磷酸二酯酶级联反应]

[The enzymology of visual reception: phosphodiesterase cascade of signal amplification].

作者信息

Filippov P P

出版信息

Biokhimiia. 1989 May;54(5):769-73.

PMID:2547457
Abstract

According to present-day concepts an important and, presumably, a key role in signal transmission in photoreceptor cells is ascribed to a system containing the photosensitive protein rhodopsin, GTP-binding protein transducin and cyclic GMP phosphodiesterase which in many features is similar to the adenylate cyclase system from other eukaryotic cells. The experimental and literary data concerning the already established and hypothetical mechanisms of transmission, enhancement and switch-off of the signal in the rhodopsin----transducin----phosphodiesterase chain are reviewed.

摘要

根据现代概念,在光感受器细胞的信号传递中,一个重要且可能是关键的作用被归于一个包含光敏蛋白视紫红质、GTP结合蛋白转导素和环鸟苷酸磷酸二酯酶的系统,该系统在许多方面与其他真核细胞的腺苷酸环化酶系统相似。本文综述了关于视紫红质 - 转导素 - 磷酸二酯酶链中信号传递、增强和关闭的已确立及假设机制的实验和文献数据。

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