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阿普司特

Apremilast.

作者信息

Cada Dennis J, Ingram Kyle, Baker Danial E

机构信息

Founder and Contributing Editor, The Formulary , Washington State University , Spokane, Washington.

Drug Information Resident, Drug Information Center, Washington State University , Spokane, Washington.

出版信息

Hosp Pharm. 2014 Sep;49(8):752-62. doi: 10.1310/hpj4908-752.

DOI:10.1310/hpj4908-752
PMID:25477601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4252204/
Abstract

Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are sent in print and are also available on-line. Monographs can be customized to meet the needs of a facility. A drug class review is now published monthly with The Formulary Monograph Service. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service, call The Formulary at 800-322-4349. The September 2014 monograph topics are tedizolid phosphate, ceritinib, omega-3-carboxylic acids, umeclidinium bromide inhalation powder, and siltuximab. The DUE/MUE is on avoidance of insulin use errors.

摘要

每月,《处方集专论服务》的订阅者会收到5至6篇关于新发布或处于3期临床试验后期药物的详细记录专论。这些专论面向药学与治疗学委员会。订阅者每月还会收到关于对议程以及药学/护理在职培训有用药物的1页摘要专论。每月还会提供一份全面的目标药物利用评估/用药使用评估(DUE/MUE)。订阅后,专论会以印刷形式发送,也可在线获取。专论可进行定制以满足机构的需求。现在每月会随《处方集专论服务》发布一份药物类别综述。通过《处方集》的合作,《医院药学》在本专栏发表精选综述。如需了解更多关于《处方集专论服务》的信息,请致电《处方集》800 - 322 - 4349。2014年9月的专论主题为磷酸特地唑胺、色瑞替尼、ω-3羧酸、乌美溴铵吸入粉和西妥昔单抗。DUE/MUE的主题是避免胰岛素使用错误。

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本文引用的文献

1
Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement: a phase III, randomised, controlled trial (PALACE 3).阿普司特,一种口服磷酸二酯酶4抑制剂,用于治疗银屑病关节炎伴皮肤受累患者:一项III期随机对照试验(PALACE 3)。
Ann Rheum Dis. 2016 Jun;75(6):1065-73. doi: 10.1136/annrheumdis-2015-207963. Epub 2016 Jan 20.
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Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1).阿普米司特,一种口服磷酸二酯酶 4(PDE4)抑制剂,用于治疗中重度斑块状银屑病患者:一项 III 期、随机、对照试验(评估阿普米司特治疗银屑病的疗效和安全性试验 [ESTEEM] 1)的结果。
J Am Acad Dermatol. 2015 Jul;73(1):37-49. doi: 10.1016/j.jaad.2015.03.049.
3
Treatment of psoriatic arthritis in a phase 3 randomised, placebo-controlled trial with apremilast, an oral phosphodiesterase 4 inhibitor.在一项口服磷酸二酯酶 4 抑制剂阿普米司特的 3 期随机、安慰剂对照试验中治疗银屑病关节炎。
Ann Rheum Dis. 2014 Jun;73(6):1020-6. doi: 10.1136/annrheumdis-2013-205056. Epub 2014 Mar 4.
4
Efficacy and safety of apremilast in subjects with moderate to severe plaque psoriasis: results from a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison study.阿普米司特治疗中重度斑块状银屑病的疗效和安全性:一项 II 期、多中心、随机、双盲、安慰剂对照、平行分组、剂量比较研究的结果。
J Eur Acad Dermatol Venereol. 2013 Mar;27(3):e376-83. doi: 10.1111/j.1468-3083.2012.04716.x. Epub 2012 Oct 3.
5
Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in ankylosing spondylitis.阿普米司特(一种口服磷酸二酯酶 4 抑制剂)治疗强直性脊柱炎的疗效和安全性。
Ann Rheum Dis. 2013 Sep 1;72(9):1475-80. doi: 10.1136/annrheumdis-2012-201915. Epub 2012 Sep 14.
6
Oral apremilast in the treatment of active psoriatic arthritis: results of a multicenter, randomized, double-blind, placebo-controlled study.口服阿普司特治疗活动性银屑病关节炎:一项多中心、随机、双盲、安慰剂对照研究的结果
Arthritis Rheum. 2012 Oct;64(10):3156-67. doi: 10.1002/art.34627.
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Efficacy of apremilast in the treatment of moderate to severe psoriasis: a randomised controlled trial.阿普米司特治疗中重度银屑病的疗效:一项随机对照试验。
Lancet. 2012 Aug 25;380(9843):738-46. doi: 10.1016/S0140-6736(12)60642-4. Epub 2012 Jun 29.
8
A phase 2, open-label, investigator-initiated study to evaluate the safety and efficacy of apremilast in subjects with recalcitrant allergic contact or atopic dermatitis.一项2期、开放标签、研究者发起的研究,旨在评估阿普米司特在顽固性过敏性接触性皮炎或特应性皮炎受试者中的安全性和有效性。
J Drugs Dermatol. 2012 Mar;11(3):341-6.
9
Apremilast mechanism of action and application to psoriasis and psoriatic arthritis.阿普米司特的作用机制及其在银屑病和银屑病关节炎中的应用。
Biochem Pharmacol. 2012 Jun 15;83(12):1583-90. doi: 10.1016/j.bcp.2012.01.001. Epub 2012 Jan 10.
10
Disposition, metabolism and mass balance of [(14)C]apremilast following oral administration.口服给予[(14)C]阿普司特后的处置、代谢及质量平衡
Xenobiotica. 2011 Dec;41(12):1063-75. doi: 10.3109/00498254.2011.604745. Epub 2011 Aug 23.