紧密连接蛋白JAM-A作为轮状病毒进入MA104细胞的共受体发挥作用。
The tight junction protein JAM-A functions as coreceptor for rotavirus entry into MA104 cells.
作者信息
Torres-Flores Jesús M, Silva-Ayala Daniela, Espinoza Marco A, López Susana, Arias Carlos F
机构信息
Instituto de Biotecnología, Universidad Nacional Autónoma de México. Avenida Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos 62210, México.
出版信息
Virology. 2015 Jan 15;475:172-8. doi: 10.1016/j.virol.2014.11.016. Epub 2014 Dec 5.
Several molecules have been identified as receptors or coreceptors for rotavirus infection, including glycans, integrins, and hsc70. In this work we report that the tight junction proteins JAM-A, occludin, and ZO-1 play an important role during rotavirus entry into MA104 cells. JAM-A was found to function as coreceptor for rotavirus strains RRV, Wa, and UK, but not for rotavirus YM. Reassortant viruses derived from rotaviruses RRV and YM showed that the virus spike protein VP4 determines the use of JAM-A as coreceptor.
几种分子已被确定为轮状病毒感染的受体或共受体，包括聚糖、整合素和热休克蛋白70。在本研究中，我们报告紧密连接蛋白JAM-A、闭合蛋白和ZO-1在轮状病毒进入MA104细胞的过程中发挥重要作用。发现JAM-A作为轮状病毒RRV、Wa和UK株的共受体，但不是轮状病毒YM的共受体。源自轮状病毒RRV和YM的重配病毒表明，病毒刺突蛋白VP4决定了JAM-A作为共受体的使用情况。
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