疾病与癌症中的磷脂酶C及磷脂酰肌醇-3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白信号通路
PLC and PI3K/Akt/mTOR signalling in disease and cancer.
作者信息
Follo Matilde Y, Manzoli Lucia, Poli Alessandro, McCubrey James A, Cocco Lucio
机构信息
Department of Biomedical and Neuromotor Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy.
Department of Biomedical and Neuromotor Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy.
出版信息
Adv Biol Regul. 2015 Jan;57:10-6. doi: 10.1016/j.jbior.2014.10.004. Epub 2014 Nov 26.
Cancer cell metabolism is deregulated, and signalling pathways can be involved. For instance, PI3K/Akt/mTOR is associated with normal proliferation and differentiation, and its alteration is detectable in cancer cells, that exploit the normal mechanisms to overcome apoptosis. On the other hand, also the family of Phospholipase C (PLC) enzymes play a critical role in cell growth, and any change concerning these enzymes or their downstream targets can be associated with neoplastic transformation. Here, we review the role of PLC and PI3K/Akt/mTOR signal transduction pathways in pathophysiology.
癌细胞代谢失调，信号通路可能参与其中。例如，PI3K/Akt/mTOR与正常的增殖和分化相关，其改变在癌细胞中可被检测到，癌细胞利用正常机制来克服细胞凋亡。另一方面，磷脂酶C（PLC）家族的酶在细胞生长中也起着关键作用，这些酶或其下游靶点的任何变化都可能与肿瘤转化相关。在此，我们综述PLC和PI3K/Akt/mTOR信号转导通路在病理生理学中的作用。
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