[巴氯芬超说明书用药的临时建议：CAMTEA系统开方者的观点]
[Temporary recommendation for use on off-label baclofen: viewpoint of Prescribers of the CAMTEA system].
作者信息
Rolland Benjamin, Deheul Sylvie, Danel Thierry, Bence Camille, Blanquart Marie-Christine, Bonord Alexandre, Semal Robin, Briand Thierry, Sochala Michel, Dubocage Christelle, Dupriez François, Duquesne Damien, Gibour Bernard, Loosfeld Xavier, Henebelle Dorothée, Henon Michael, Vernalde Elodie, Matton Christian, Bacquet Jean-Eudes, Molmy Lucie, Sarasy François, Simioni Nicolas, Richez Cécile, Gentil-Spinosi Laure, Vosgien Véronique, Yguel Jacques, Ledent Thierry, Auffret Marine, Wilquin Maroussia, Ziolkowski Danièle, Sochala Michel, Gautier Sophie, Bordet Régis, Cottencin Olivier
机构信息
Université Lille Nord de France, Lille, France - Service d'addictologie, Hôpital Fontan 2, CHRU de Lille, Lille, France.
Centre d'évaluation et d'information sur la pharmacodépendance, CHRU de Lille, Lille, France.
出版信息
Therapie. 2015 Mar-Apr;70(2):235-8. doi: 10.2515/therapie/2014210. Epub 2014 Dec 10.
The use of high dose baclofen for alcohol-dependence emerged in France from 2008 based on empirical findings, and is still off-label. However, due to the rapid increase in this prescribing practice, the French health authorities have decided to frame it using an extraordinary regulatory measure named "temporary recommendation for use" (TRU). Baclofen prescribers from CAMTEA, a regional team-based off-label system for supervising baclofen prescribing, which was developed much prior to the TRU, discuss herein the pros and cons of this measure and the applicability of its different aspects in the daily clinical practice.
基于实证研究结果，高剂量巴氯芬用于治疗酒精依赖于2008年在法国出现，目前仍属于超适应症用药。然而，由于这种处方行为迅速增加，法国卫生当局决定采用一种名为“临时使用建议”（TRU）的特殊监管措施对其进行规范。CAMTEA是一个基于区域团队的超适应症用药监管系统，用于监督巴氯芬的处方，该系统在TRU出台之前就已开发，来自该系统的巴氯芬处方医生在此讨论了这一措施的利弊及其不同方面在日常临床实践中的适用性。
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