研究帕金森病中快速眼动睡眠期无张力缺失现象的夜间变异性。
Investigating the night-to-night variability of REM without atonia in Parkinson's disease.
作者信息
Bolitho Samuel J, Naismith Sharon L, Terpening Zoe, Grunstein Ron R, Melehan Kerri, Yee Brendon J, Coeytaux Alessandra, Lewis Simon J G
机构信息
Parkinson's Disease Research Clinic, Brain and Mind Research Institute, The University of Sydney, NSW, Australia.
Healthy Brain Ageing Clinic, Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, NSW, Australia.
出版信息
Sleep Med. 2015 Jan;16(1):190-3. doi: 10.1016/j.sleep.2014.08.007. Epub 2014 Sep 20.
OBJECTIVES
Rapid eye movement (REM) sleep behaviour disorder is frequently observed in Parkinson's disease and is characterized electrophysiologically by the absence of atonia during REM sleep. However, the night-to-night variability of REM sleep without atonia is yet to be determined in Parkinson's disease.
METHODS
Using polysomnography, this study measured the variability of REM sleep without atonia across two consecutive nights, using the REM atonia index in 38 patients with Parkinson's disease.
RESULTS
The intraclass correlation coefficient between the REM sleep atonia index across two nights was 0.816 (F = 9.795, p < 0.001) and the difference between the two nights was 4.7% (standard deviation (SD) 8.2).
CONCLUSION
The REM atonia index demonstrated low variability across two consecutive nights of PSG. Furthermore, the diagnosis of REM sleep behaviour disorder based on this electrophysiological marker and other clinical variables was in agreement across the two nights.
目的
快速眼动（REM）睡眠行为障碍在帕金森病中较为常见，其电生理特征是REM睡眠期无肌张力缺失。然而，帕金森病中REM睡眠期无肌张力缺失的夜间变异性尚未确定。
方法
本研究采用多导睡眠图，通过38例帕金森病患者的REM肌张力缺失指数，测量连续两晚REM睡眠期无肌张力缺失的变异性。
结果
两晚REM睡眠肌张力缺失指数的组内相关系数为0.816（F = 9.795，p < 0.001），两晚之间的差异为4.7%（标准差（SD）8.2）。
结论
多导睡眠图连续两晚的REM肌张力缺失指数显示出低变异性。此外，基于该电生理指标和其他临床变量对REM睡眠行为障碍的诊断在两晚之间是一致的。
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