用于生物医学和个人护理应用的球霰石型碳酸钙微粒

CaCO₃ vaterite microparticles for biomedical and personal care applications.

作者信息

Trushina Daria B, Bukreeva Tatiana V, Kovalchuk Mikhail V, Antipina Maria N

机构信息

Institute of Materials Research and Engineering, A*STAR, Singapore 117602, Singapore; Lomonosov Moscow State University, Faculty of Physics, Moscow 119991, Russia.

National Research Centre "Kurchatov Institute", Moscow 123098, Russia; A.V. Shubnikov Institute of Crystallography, Moscow 119333, Russia.

出版信息

Mater Sci Eng C Mater Biol Appl. 2014 Dec;45:644-58. doi: 10.1016/j.msec.2014.04.050. Epub 2014 May 14.

DOI:10.1016/j.msec.2014.04.050

PMID:25491874

Abstract

Among the polymorph modifications of calcium carbonate, the metastable vaterite is the most practically important. Vaterite particles are applied in regenerative medicine, drug delivery and a broad range of personal care products. This manuscript scopes to review the mechanism of the calcium carbonate crystal growth highlighting the factors stabilizing the vaterite polymorph in the most cost efficient synthesis routine. The size of vaterite particles is a crucial parameter for practical applications. The options for tuning the particle size are also discussed.

摘要

在碳酸钙的多晶型变体中，亚稳态的球霰石在实际应用中最为重要。球霰石颗粒被应用于再生医学、药物递送以及广泛的个人护理产品中。本文旨在综述碳酸钙晶体生长的机制，重点强调在最具成本效益的合成流程中稳定球霰石多晶型的因素。球霰石颗粒的尺寸是实际应用中的一个关键参数。本文还讨论了调节颗粒尺寸的方法。