[他汀类药物对脓毒症诱导的急性肾损伤的抗氧化保护作用]
[Antioxidant protection of statins in acute kidney injury induced by sepsis].
作者信息
Santos Franciele do Nascimento, Watanabe Mirian, Vasco Carolina Ferreira, Fonseca Cassiane Dezoti da, Vattimo Maria de Fatima Fernandes
机构信息
School of Nursing, Universidade de São Paulo, São Paulo, SP, Brazil.
Department of Medical-Surgical Nursing, Universidade de São Paulo, São Paulo, SP, Brazil.
出版信息
Rev Esc Enferm USP. 2014 Oct;48(5):820-6. doi: 10.1590/s0080-6234201400005000007.
OBJECTIVE
Evaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis.
METHOD
Male adult Wistar rats were divided into the following groups: SHAM (control); SHAM+Statin (0.5 mg/kg simvastatin, orally); Sepsis (cecal puncture ligation - CPL); Sepsis+Statin. Physiological parameters, peritoneal fluid culture, renal function, oxidative metabolites, severity of acute kidney injury and animal survival were evaluated.
RESULTS
The treatment with simvastatin in induced sepsis showed elevation of creatinine clearance with attenuation of generation of oxidative metabolites, lower severity of acute kidney injury and reduced mortality.
CONCLUSION
This investigation confirmed the renoprotection with antioxidant principle of the simvastatin in acute kidney injury induced by sepsis in an experimental model.
目的
评估辛伐他汀预处理对脓毒症诱导的急性肾损伤的影响。
方法
将成年雄性Wistar大鼠分为以下几组：假手术组（对照组）；假手术+他汀组（口服0.5mg/kg辛伐他汀）；脓毒症组（盲肠穿刺结扎术）；脓毒症+他汀组。评估生理参数、腹腔液培养、肾功能、氧化代谢产物、急性肾损伤严重程度及动物存活率。
结果
在诱导的脓毒症中，辛伐他汀治疗使肌酐清除率升高，氧化代谢产物生成减少，急性肾损伤严重程度降低，死亡率降低。
结论
本研究证实在实验模型中，辛伐他汀的抗氧化原理对脓毒症诱导的急性肾损伤具有肾脏保护作用。
Zotero 插件