Horowitz-Kraus Tzipi, Grainger Molly, DiFrancesco Mark, Vannest Jennifer, Holland Scott K
Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA,
Brain Imaging Behav. 2015 Mar;9(1):19-31. doi: 10.1007/s11682-014-9341-9.
The Simple View theory suggests that reading comprehension relies on automatic recognition of words combined with language comprehension. The goal of the current study was to examine the structural and functional connectivity in networks supporting reading comprehension and their relationship with language comprehension within 7-9 year old children using Diffusion Tensor Imaging (DTI) and fMRI during a Sentence Picture Matching task. Fractional Anisotropy (FA) values in the left and right Inferior Longitudinal Fasciculus (ILF) and Superior Longitudinal Fasciculus (SLF), known language-related tracts, were correlated from DTI data with scores from the Woodcock-Johnson III (WJ-III) Passage Comprehension sub-test. Brodmann areas most proximal to white-matter regions with significant correlation to Passage Comprehension scores were chosen as Regions-of-Interest (ROIs) and used as seeds in a functional connectivity analysis using the Sentence Picture Matching task. The correlation between percentile scores for the WJ-III Passage Comprehension subtest and the FA values in the right and left ILF and SLF indicated positive correlation in language-related ROIs, with greater distribution in the right hemisphere, which in turn showed strong connectivity in the fMRI data from the Sentence Picture Matching task. These results support the participation of the right hemisphere in reading comprehension and may provide physiologic support for a distinction between different types of reading comprehension deficits vs difficulties in technical reading.
简单视图理论认为，阅读理解依赖于单词的自动识别与语言理解相结合。本研究的目的是在7至9岁儿童进行句子图片匹配任务期间，使用扩散张量成像（DTI）和功能磁共振成像（fMRI）来检查支持阅读理解的网络中的结构和功能连接，以及它们与语言理解之间的关系。从DTI数据中获取左、右颞下纵束（ILF）和上纵束（SLF）（已知的与语言相关的神经束）的分数各向异性（FA）值，并将其与伍德库克-约翰逊III（WJ-III）段落理解子测试的分数进行关联。选择与段落理解分数有显著相关性的白质区域最接近的布罗德曼区域作为感兴趣区域（ROI），并在使用句子图片匹配任务的功能连接分析中用作种子。WJ-III段落理解子测试的百分位数分数与左、右ILF和SLF中的FA值之间的相关性表明，在与语言相关的ROI中存在正相关，且在右半球分布更广泛，这反过来在句子图片匹配任务的fMRI数据中显示出很强的连接性。这些结果支持右半球参与阅读理解，并可能为区分不同类型的阅读理解缺陷与技术阅读困难提供生理支持。
