多能干细胞衍生的心外膜细胞：迈向人工心脏组织的一步。
Pluripotent-stem-cell-derived epicardial cells: a step toward artificial cardiac tissue.
机构信息
Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
出版信息
Cell Stem Cell. 2014 Nov 6;15(5):533-4. doi: 10.1016/j.stem.2014.10.007.
PMID:25517459
Abstract
Epicardial cells are crucial for heart development, function, and regeneration, but methods to study them have been lacking. Using WNT and BMP signaling pathways, Witty et al. (2014) have now developed an elaborate method to generate fully functional epicardial cells from human pluripotent stem cells, allowing their in vitro investigation.
摘要
心外膜细胞对于心脏的发育、功能和再生至关重要，但目前缺乏研究它们的方法。Witty 等人（2014 年）利用 WNT 和 BMP 信号通路，现在开发出一种从人类多能干细胞生成完全功能的心外膜细胞的精细方法，从而可以在体外对其进行研究。
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