Arnedo-Pena A, Juan-Cerdán J V, Romeu-García A, García-Ferrer D, Holguín-Gómez R, Iborra-Millet J, Gil-Fortuño M, Gomila-Sard B, Roach-Poblete F
Epidemiology Division, Public Health Centre, Castellón, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Barcelona, Spain.
Biochemical Laboratory, Hospital General, Castellón, Spain.
Int J Tuberc Lung Dis. 2015 Jan;19(1):65-9. doi: 10.5588/ijtld.14.0348.
A prospective cohort study was conducted from 2009 to 2012 to assess the relationship between serum baseline 25-hydroxivytamin D (vitamin D) status and the incidence of tuberculosis (TB) among 572 contacts of 89 pulmonary TB patients in Castellon, Spain. Three new cases of pulmonary TB occurred, with an incidence density of 3.6 per 1000 person-years. Mean vitamin D status was 13.7 ng/ml for cases and 25.7 ng/ml for non-cases. Vitamin D status showed a significant inverse association with TB incidence (adjusted HR 0.88, 95%CI 0.80-0.97). This result is in line with the hypothesis that vitamin D deficiency is associated with TB incidence.
2009年至2012年开展了一项前瞻性队列研究，以评估西班牙卡斯特利翁89例肺结核患者的572名接触者血清基线25-羟维生素D（维生素D）状态与结核病（TB）发病率之间的关系。发生了3例新发肺结核病例，发病密度为每1000人年3.6例。病例组的平均维生素D水平为13.7 ng/ml，非病例组为25.7 ng/ml。维生素D状态与结核病发病率呈显著负相关（校正风险比0.88，95%置信区间0.80-0.97）。这一结果与维生素D缺乏与结核病发病率相关的假设一致。
