Vescovi P P, Pedrazzoni M, Gerra G, Pioli G, Maninetti L, Michelini M, Passeri M
Instituto di Clinica Medica Generale e Terapia Medica, Università di Parma, Italy.
Acta Endocrinol (Copenh). 1989 Oct;121(4):484-8. doi: 10.1530/acta.0.1210484.
To evaluate the responses of circulating beta-endorphin, met-enkephalin and ACTH to sauna-induced hyperthermia, 8 male heroin addicts recently admitted to a therapeutic community and 8 age-matched normal subjects were examined. Compared with control subjects, heroin addicts showed 1. A decrease of the basal levels of beta-endorphin; 2. Absence of the normal increase of beta-endorphin and ACTH after sauna; 3. A lower increase in systolic blood pressure. It is concluded that an impairment of the adaptive response to stress may be present in heroin addicts, even after a relatively short drug-free period (14 days).
为评估循环β-内啡肽、甲硫氨酸脑啡肽和促肾上腺皮质激素（ACTH）对桑拿诱导的体温过高的反应，对8名最近进入治疗社区的男性海洛因成瘾者和8名年龄匹配的正常受试者进行了检查。与对照组相比，海洛因成瘾者表现为：1. β-内啡肽基础水平降低；2. 桑拿后β-内啡肽和ACTH未出现正常升高；3. 收缩压升高幅度较低。结论是，即使在相对较短的戒毒期（14天）后，海洛因成瘾者可能仍存在对应激的适应性反应受损的情况。
