一种用于用近红外诊疗剂标记蛋白质和纳米颗粒的新型荧光显色点击反应。
A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents.
作者信息
Planas Oriol, Gallavardin Thibault, Nonell Santi
机构信息
Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta, 390, 08017, Barcelona, Spain.
出版信息
Chem Commun (Camb). 2015 Apr 4;51(26):5586-9. doi: 10.1039/c4cc09070e.
PMID:25531206
Abstract
Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The conjugates show fluorescence in the near-infrared and are capable of photosensitizing the production of the cytotoxic species singlet oxygen.
摘要
异硫氰酸卟吩与伯胺和仲胺反应生成噻唑并[4,5-c]卟吩，其吸收光谱和荧光光谱发生显著变化。这些共轭物在近红外区域显示荧光，并且能够使细胞毒性物质单线态氧的产生发生光致敏作用。
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