乳腺浸润性导管癌中肿瘤大小小于1厘米时的组织学分级（HG）：从HG1进展到HG3过程中的临床及生物学关联

Histological grade (HG) in invasive ductal carcinomas of the breast of less than 1 cm: clinical and biological associations during progression from HG1 to HG3.

作者信息

Ruibal Álvaro, Aguiar Pablo, Del Rio María Carmen, Arias José Ignacio, Menéndez-Rodríguez Primitiva, Gude Francisco, Herranz Michel

机构信息

Molecular Imaging Group, Nuclear Medicine Service, University Hospital of Santiago de Compostela, IDIS, Santiago de Compostela, Spain Molecular Imaging and Medical Physics Group, Faculty of Medicine, University of Santiago de Compostela (USC), Santiago de Compostela, Spain Tejerina Foundation, Madrid, Spain.

出版信息

Anticancer Res. 2015 Jan;35(1):569-73.

PMID:25550604

Abstract

AIM

To study the clinical and biological (cellular proliferation and hormone-dependence) associations during the progression of histological grade (HG), from HG1 to HG3, in invasive ductal carcinomas of the breast (IDC) <1 cm.

PATIENTS AND METHODS

The study group included 119 women with IDCs ≤1 cm, aged between 27 and 88 years (median=61 years). The parameters analyzed were: histological grade (HG1: 52; HG2: 45; HG3: 22); axillary lymph node involvement (N); distant metastasis (M); and immunohistochemical expression of estrogen (ER), progesterone (PR) and androgen (AR) receptors, and Ki67, p53 and B-cell lymphoma 2 (BCL2).

RESULTS

Compared to HG3 tumors, HG1s exhibited an increased expression of ER, AR and BCL2, as well as lower expression of p53 and Ki67. In HG1 tumors, significant (p<0.05) associations were found between ER and PR (positive), ER and p53 (negative), ER and Ki67 (negative), PR and AR (positive), PR and p53 (negative), AR and p53 (negative), p53 and BCL2 (negative), and between BCL2 and Ki67 (negative). HG3s only showed significant (p<0.05) associations between ER and Ki-67 (negative) and between BCL2 or Ki-67 (negative). Only two significant relationships (ER-Ki67 and BCL2-Ki67) persisted in all three grades.

CONCLUSION

Our results lead us to the following conclusions: i) compared HG1, HG3 ductal carcinomas exhibited decreased expression of ER, AR and BCL2 and increased expression of p53 and Ki67; and ii) only two significant and negative relations (ER-Ki67 and BCL2-Ki67) persisted in all three grades.

摘要

目的

研究乳腺浸润性导管癌（IDC）直径<1 cm，组织学分级（HG）从HG1进展至HG3过程中的临床及生物学（细胞增殖和激素依赖性）关联。

患者与方法

研究组包括119例IDC≤1 cm的女性，年龄在27至88岁之间（中位数=61岁）。分析的参数包括：组织学分级（HG1：52例；HG2：45例；HG3：22例）；腋窝淋巴结受累情况（N）；远处转移情况（M）；雌激素（ER）、孕激素（PR）和雄激素（AR）受体以及Ki67、p53和B细胞淋巴瘤2（BCL2）的免疫组化表达。

结果

与HG3肿瘤相比，HG1肿瘤的ER、AR和BCL2表达增加，p53和Ki67表达降低。在HG1肿瘤中，发现ER与PR（阳性）、ER与p53（阴性）、ER与Ki67（阴性）、PR与AR（阳性）、PR与p53（阴性）、AR与p53（阴性）、p53与BCL2（阴性）以及BCL2与Ki67（阴性）之间存在显著（p<0.05）关联。HG3肿瘤仅显示ER与Ki-67（阴性）以及BCL2或Ki-67（阴性）之间存在显著（p<0.05）关联。仅两种显著关系（ER-Ki67和BCL2-Ki67）在所有三个分级中均持续存在。