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The optimized anti-CD20 monoclonal antibody ublituximab bypasses natural killer phenotypic features in Waldenström macroglobulinemia.

作者信息

Le Garff-Tavernier Magali, Herbi Linda, de Romeuf Christophe, Azar Nabih, Roos-Weil Damien, Bonnemye Patrick, Urbain Rémi, Leblond Véronique, Merle-Beral Hélène, Vieillard Vincent

机构信息

Sorbonne Universités, UPMC, Univ Paris 06, Paris INSERM U1135, CIMI-Paris AP-HP, Hôpital Pitié-Salpêtrière, Service d'Hématologie Biologique, Paris

Sorbonne Universités, UPMC, Univ Paris 06, Paris INSERM U1135, CIMI-Paris Laboratoire Français de Fractionnement et des Biotechnologies (LFB), Les Ulis.

出版信息

Haematologica. 2015 Apr;100(4):e147-51. doi: 10.3324/haematol.2014.118083. Epub 2014 Dec 31.

Abstract
摘要

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Hematological malignancies escape from NK cell innate immune surveillance: mechanisms and therapeutic implications.
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Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education.
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