表达狂犬病病毒G蛋白的副流感病毒5在狂犬病病毒感染后可保护小鼠。
Parainfluenza virus 5 expressing the G protein of rabies virus protects mice after rabies virus infection.
作者信息
Huang Ying, Chen Zhenhai, Huang Junhua, Fu ZhenFang, He Biao
机构信息
Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.
Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.
出版信息
J Virol. 2015 Mar;89(6):3427-9. doi: 10.1128/JVI.03656-14. Epub 2014 Dec 31.
Abstract
Rabies remains a major public health threat around the world. Once symptoms appear, there is no effective treatment to prevent death. In this work, we tested a recombinant parainfluenza virus 5 (PIV5) strain expressing the glycoprotein (G) of rabies (PIV5-G) as a therapy for rabies virus infection: we have found that PIV5-G protected mice as late as 6 days after rabies virus infection. PIV5-G is a promising vaccine for prevention and treatment of rabies virus infection.
摘要
狂犬病在全球范围内仍然是一个重大的公共卫生威胁。一旦出现症状，就没有有效的治疗方法来预防死亡。在这项研究中，我们测试了一种表达狂犬病糖蛋白（G）的重组副流感病毒5（PIV5）株（PIV5-G）作为狂犬病病毒感染的治疗方法：我们发现PIV5-G在狂犬病病毒感染后长达6天仍能保护小鼠。PIV5-G是一种有前景的预防和治疗狂犬病病毒感染的疫苗。
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