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学龄儿童早晨的皮质醇分泌与前一晚的睡眠模式有关。

Morning cortisol secretion in school-age children is related to the sleep pattern of the preceding night.

作者信息

Lemola Sakari, Perkinson-Gloor Nadine, Hagmann-von Arx Priska, Brand Serge, Holsboer-Trachsler Edith, Grob Alexander, Weber Peter

机构信息

Department of Psychology, University of Basel, Missionsstrasse 62, 4055 Basel, Switzerland.

Center for Affective, Stress and Sleep Disorders, Psychiatric Clinics of the University of Basel, Wilhelm Klein-Strasse 27, 4014 Basel, Switzerland; Department of Sport, Exercise and Health, Division of Sport Science, Faculty of Medicine, University of Basel, Birsstrasse 320 B, 4052 Basel, Switzerland.

出版信息

Psychoneuroendocrinology. 2015 Feb;52:297-301. doi: 10.1016/j.psyneuen.2014.12.007. Epub 2014 Dec 15.

Abstract

Sleep disturbance in childhood is common and a risk factor for poor mental health. Evidence indicates that disturbed sleep is associated with altered hypothalamic-pituitary-adrenal axis (HPAA) activity. Knowledge regarding the association between HPAA-activity and objective sleep measures particularly regarding sleep architecture in school-age children is missing. Sleep-electroencephalography was administered to 113 children aged 6-10 years (including 58 children born very preterm and 55 born at term) during one night at the children's homes and sleep duration, sleep continuity, and sleep architecture were assessed. To assess the cortisol awakening response at the following morning, cortisol secretion was measured at awakening, 10, 20, and 30min later. Regression analyses controlling child age, gender, prematurity status, and the awakening time revealed that morning cortisol secretion was negatively associated with sleep duration and slow wave sleep and positively associated with the relative amount of Stage 2 sleep during the preceding night. In addition, morning cortisol secretion linearly increased with age. In conclusion, associations of sleep disturbance with poor mental health may be confounded with altered HPAA-activity.

摘要

儿童睡眠障碍很常见,且是心理健康不佳的一个风险因素。有证据表明,睡眠障碍与下丘脑-垂体-肾上腺轴(HPAA)活动改变有关。关于HPAA活动与客观睡眠指标之间的关联,尤其是学龄儿童睡眠结构方面的知识尚属空白。在孩子们家中对113名6至10岁儿童(包括58名极早产儿童和55名足月儿)进行了睡眠脑电图监测,评估了睡眠时间、睡眠连续性和睡眠结构。为了评估次日早晨的皮质醇觉醒反应,在觉醒时、10分钟、20分钟和30分钟后测量皮质醇分泌。控制儿童年龄、性别、早产状态和觉醒时间的回归分析显示,早晨皮质醇分泌与睡眠时间和慢波睡眠呈负相关,与前一晚第二阶段睡眠的相对量呈正相关。此外,早晨皮质醇分泌随年龄呈线性增加。总之,睡眠障碍与心理健康不佳之间的关联可能与HPAA活动改变相互混淆。

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