Department of Biology, College of Arts and Science, University of Saskatchewan, W.P. Thompson Building 112 Science Place, Saskatoon, Saskatchewan, S7N5E2, Canada.
Department of Biology, College of Arts and Science, University of Saskatchewan, W.P. Thompson Building 112 Science Place, Saskatoon, Saskatchewan, S7N5E2, Canada; Vaccine and Infectious Disease Organization-International Vaccine Center (VIDO-InterVac), University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, S7N5E3, Canada.
Microbes Infect. 2015 Apr;17(4):317-22. doi: 10.1016/j.micinf.2014.12.012. Epub 2014 Dec 29.
In gonococci-infected transduced human urethral epithelial cells (THUEC), the role of ERK, a mitogen-activated protein kinase (MAPK), in apoptosis is unknown. We observed lowering of ERK activation in THUEC following infection with anti-apoptosis-inducing Neisseria gonorrhoeae strain CH811. An isogenic cell division mutant of this strain, Ng CJSD1 (minD deficient), which is large and abnormally shaped, reduced ERK phosphorylation levels even more than its parental strain in THUEC. This led to higher anti-apoptosis in mutant-infected cells as compared to the parental strain-infected cells. Our results suggest that N. gonorrhoeae infection reduces ERK activation in THUEC contributing to anti-apoptosis.
在感染淋病奈瑟菌的转导人尿道上皮细胞（THUEC）中，丝裂原活化蛋白激酶（MAPK）ERK 在细胞凋亡中的作用尚不清楚。我们观察到，抗凋亡诱导淋病奈瑟菌 CH811 株感染后 THUEC 中的 ERK 激活降低。该菌株的同基因细胞分裂突变体 Ng CJSD1（minD 缺陷），体积大且形状异常，与亲本株相比，在 THUEC 中甚至降低了 ERK 磷酸化水平。这导致突变体感染细胞的抗凋亡作用高于亲本株感染细胞。我们的结果表明，淋病奈瑟菌感染降低了 THUEC 中的 ERK 激活，有助于抗凋亡。
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