在正常压力脑积水患者分流植入术后，阿司匹林与硬膜下血肿风险增加相关。
Aspirin is associated with an increased risk of subdural hematoma in normal-pressure hydrocephalus patients following shunt implantation.
作者信息
Birkeland Peter, Lauritsen Jens, Poulsen Frantz Rom
机构信息
Departments of 1 Neurosurgery and.
Orthopedic Surgery, Odense University Hospital; and.
出版信息
J Neurosurg. 2015 Aug;123(2):423-6. doi: 10.3171/2014.11.JNS14804. Epub 2015 Jan 2.
OBJECT
In this paper the authors investigate whether shunt-treated patients with normal-pressure hydrocephalus receiving aspirin therapy are at increased risk of developing subdural hematoma (SDH).
METHODS
Records from 80 consecutive patients who had undergone implantation of a cerebrospinal fluid shunt for the treatment of normal-pressure hydrocephalus were retrospectively reviewed.
RESULTS
Eleven cases of symptomatic SDH occurred, all among patients receiving aspirin or clopidogrel. The 5-year survival estimate was 0.3 (p < 0.0001) for users of aspirin and the hazard ratio was 12.8 (95% CI 3.1-53).
CONCLUSIONS
Patients on an aspirin therapy regimen have a markedly increased risk of SDH after a shunt has been implanted for the treatment of normal-pressure hydrocephalus. Users of clopidogrel may have an even greater risk.
目的
在本文中，作者调查接受阿司匹林治疗的正常压力脑积水分流治疗患者发生硬膜下血肿（SDH）的风险是否增加。
方法
回顾性分析80例因正常压力脑积水接受脑脊液分流植入术的连续患者的记录。
结果
发生11例有症状的SDH，均发生在接受阿司匹林或氯吡格雷治疗的患者中。阿司匹林使用者的5年生存估计值为0.3（p<0.0001），风险比为12.8（95%CI 3.1-53）。
结论
接受阿司匹林治疗方案的患者在因正常压力脑积水植入分流器后发生SDH的风险显著增加。氯吡格雷使用者的风险可能更大。
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