痉挛型脑瘫患儿腓肠肌内侧组织成分的超声特征分析
Ultrasound characterization of medial gastrocnemius tissue composition in children with spastic cerebral palsy.
作者信息
Pitcher Christian A, Elliott Catherine M, Panizzolo Fausto A, Valentine Jane P, Stannage Katherine, Reid Siobhán L
机构信息
School of Sport Science, Exercise and Health, The University of Western Australia, 35 Stirling Highway, Crawley, 6009, Western Australia, Australia.
Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.
出版信息
Muscle Nerve. 2015 Sep;52(3):397-403. doi: 10.1002/mus.24549. Epub 2015 Jun 18.
INTRODUCTION
In this study we aimed to characterize muscle composition of the medial gastrocnemius in children with spastic cerebral palsy (SCP) using quantitative ultrasound.
METHODS
Forty children with SCP, aged 4-14 years, participated in this study. Children were grouped according to the gross motor function classification system (GMFCS I-V) and compared with a cohort of age- and gender-matched, typically developing children (TD; n = 12). Ultrasound scans were taken of the medial gastrocnemius. Images were then characterized using grayscale statistics to determine mean echo intensity (EI) and the size and number of spatially connected homogeneous regions (i.e., blobs).
RESULTS
Significant differences in skeletal muscle composition were found between children with SCP and their TD peers. Children classified as GMFCS III consistently exhibited the highest EI and blob area.
CONCLUSIONS
This study demonstrates altered tissue composition in children with SCP visualized using ultrasound. Further work is required to determine the pathophysiology contributing to these alterations in SCP.
引言
在本研究中，我们旨在使用定量超声对痉挛型脑瘫（SCP）患儿的腓肠肌内侧肌肉组成进行表征。
方法
40名年龄在4至14岁之间的SCP患儿参与了本研究。根据粗大运动功能分类系统（GMFCS I - V）对患儿进行分组，并与一组年龄和性别匹配的发育正常儿童（TD；n = 12）进行比较。对腓肠肌内侧进行超声扫描。然后使用灰度统计对图像进行表征，以确定平均回声强度（EI）以及空间相连的均匀区域（即斑点）的大小和数量。
结果
发现SCP患儿与其TD同龄人之间的骨骼肌组成存在显著差异。分类为GMFCS III的患儿始终表现出最高的EI和斑点面积。
结论
本研究表明，使用超声可观察到SCP患儿的组织组成发生改变。需要进一步开展工作以确定导致SCP中这些改变的病理生理学机制。
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