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高压氧疗法治疗突发性听力损失

Management of sudden hearing loss with hyperbaric oxygen therapy.

作者信息

Gaitanou K, Fildissis G, Vavasis P, Kalentzos V, Baltopoulos G

机构信息

Department of Hyperbaric & Diving Medicine, Athens Naval Hospital.

出版信息

Undersea Hyperb Med. 2014 Sep-Oct;41(5):363-70.

Abstract

UNLABELLED

Idiopathic sudden sensorineural hearing loss (ISSHL) is defined as the sensorineural hearing loss of a minimum of 30 dB in at least three frequencies for three days or more. This study aims to evaluate the clinical efficacy of hyperbaric oxygen therapy (HBO2) in the management of idiopathic sudden sensorineural hearing loss.

MATERIAL-METHODS: Patients with ISSHL received treatment including oral corticosteroids and HBO2. HBO2 protocol included five phases of five sessions each. ISSHL was assessed by measuring the tonal audiogram before and after each phase. Tinnitus was assessed using a questionnaire and a visual analogue scale at the beginning and the end of the study. Secondary assessment points included changes in the intensity and the improvement of tinnitus.

RESULTS

56 patients were included in the study. All patients completed Phases I and II of HBO2, 43 completed Phase III, 13 completed Phase IV, and six completed all five phases. Overall, a significant improvement was noted between the initial and final audiogram after HBO2 (p < 0.001). Tinnitus evaluation score, intensity and related problems were also significantly reduced (p < 0.001).

CONCLUSION

This study affirms previous findings that the use of HBO2 and vasodilators are efficacious in the treatment of ISSHL. Our findings also suggest benefit for the treatment of tinnitus.

摘要

未标注

特发性突发性感音神经性听力损失(ISSHL)定义为至少三个频率听力损失至少30分贝且持续三天或更长时间的感音神经性听力损失。本研究旨在评估高压氧疗法(HBO2)治疗特发性突发性感音神经性听力损失的临床疗效。

材料与方法

ISSHL患者接受包括口服皮质类固醇和HBO2在内的治疗。HBO2方案包括五个阶段,每个阶段各五次治疗。通过在每个阶段前后测量纯音听力图来评估ISSHL。在研究开始和结束时使用问卷和视觉模拟量表评估耳鸣。次要评估点包括耳鸣强度的变化和改善情况。

结果

56例患者纳入研究。所有患者完成了HBO2的第一阶段和第二阶段,43例完成了第三阶段,13例完成了第四阶段,6例完成了所有五个阶段。总体而言,HBO2治疗后初始和最终听力图之间有显著改善(p < 0.001)。耳鸣评估得分、强度及相关问题也显著降低(p < 0.001)。

结论

本研究证实了先前的发现,即使用HBO2和血管扩张剂治疗ISSHL有效。我们的研究结果还表明对耳鸣治疗有益。

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