Sova Milan, Sovova Eliska, Hobzova Milada, Zapletalova Jana, Kamasova Monika, Kolek Vitezslav
Department of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.
Department of Internal Medicine I - Cardiology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Jun;159(2):277-82. doi: 10.5507/bp.2014.063. Epub 2014 Dec 22.
Obstructive sleep apnea (OSA) is a common cause of secondary arterial hypertension. Masked hypertension (MH) is defined as normal office blood pressure and abnormal results in 24 h ambulatory blood pressure monitoring (ABPM). The aim of this study was to evaluate the effect of CPAP therapy on the prevalence of MH in patients with OSA.
43 patients (40 men) were included, average age 54.2±10.5 years. All underwent sleep study (PG or PSG) with a diagnosis of OSA indicated for CPAP treatment, average apnea-hypopnea index (AHI) 60.6±23.6. Patients were treated with CPAP for one year. Ambulatory blood pressure monitoring was performed before and after one year of treatment.
Masked hypertension was initially present in 25 (58.1%) and in 26 (60.5%) patients after one year of CPAP therapy. However, there was a statistically significant improvement in BP for all evaluated intervals of ABPM with the exception of systolic pressure during the daytime.
Masked hypertension was very prevalent in these patients with OSA. The CPAP treatment for one year however had no affect on prevalence of masked hypertension although there was a positive effect of CPAP treatment on blood pressure for all assessed intervals of ABPM with the exception of systolic BP during daytime.
阻塞性睡眠呼吸暂停（OSA）是继发性动脉高血压的常见病因。隐蔽性高血压（MH）定义为诊室血压正常而24小时动态血压监测（ABPM）结果异常。本研究旨在评估持续气道正压通气（CPAP）治疗对OSA患者中MH患病率的影响。
纳入43例患者（40例男性），平均年龄54.2±10.5岁。所有患者均接受了睡眠研究（多导睡眠图或便携式睡眠监测），诊断为OSA并适合CPAP治疗，平均呼吸暂停低通气指数（AHI）为60.6±23.6。患者接受CPAP治疗1年。在治疗1年前后进行动态血压监测。
初始时有25例（58.1%）存在隐蔽性高血压，CPAP治疗1年后有26例（60.5%）存在。然而，除日间收缩压外，ABPM所有评估时间段的血压均有统计学意义的改善。
隐蔽性高血压在这些OSA患者中非常普遍。尽管CPAP治疗对ABPM所有评估时间段的血压有积极影响，但对隐蔽性高血压的患病率没有影响，日间收缩压除外。
