缺氧诱导因子1与乳腺癌转移
Hypoxia-inducible factor 1 and breast cancer metastasis.
作者信息
Liu Zhao-Ji, Semenza Gregg L, Zhang Hua-Feng
机构信息
CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Biology, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
J Zhejiang Univ Sci B. 2015 Jan;16(1):32-43. doi: 10.1631/jzus.B1400221.
Abstract
Accumulating evidence has shown that the hypoxic microenvironment, which is critical during cancer development, plays a key role in regulating breast cancer progression and metastasis. The effects of hypoxia-inducible factor 1 (HIF-1), a master regulator of the hypoxic response, have been extensively studied during these processes. In this review, we focus on the roles of HIF-1 in regulating breast cancer cell metastasis, specifically its effects on multiple key steps of metastasis, such as epithelial-mesenchymal transition (EMT), invasion, extravasation, and metastatic niche formation. We also discuss the roles of HIF-1-regulated non-coding RNAs in breast cancer metastasis, and therapeutic opportunities for breast cancer through targeting the HIF-1 pathway.
摘要
越来越多的证据表明，缺氧微环境在癌症发展过程中至关重要，在调节乳腺癌的进展和转移中起关键作用。缺氧诱导因子1（HIF-1）作为缺氧反应的主要调节因子，其作用在这些过程中已得到广泛研究。在本综述中，我们重点关注HIF-1在调节乳腺癌细胞转移中的作用，特别是其对转移多个关键步骤的影响，如上皮-间质转化（EMT）、侵袭、外渗和转移小生境形成。我们还讨论了HIF-1调节的非编码RNA在乳腺癌转移中的作用，以及通过靶向HIF-1途径治疗乳腺癌的机会。
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