Suppr超能文献

大脑半球间对支配前臂肌肉的皮质脊髓投射的抑制作用。

Interhemispheric inhibition of corticospinal projections to forearm muscles.

作者信息

Ibey R J, Bolton D A E, Buick A R, Staines W R, Carson R G

机构信息

Department of Kinesiology, University of Waterloo, Waterloo, Canada.

School of Psychology, Queen's University Belfast, Northern Ireland, UK.

出版信息

Clin Neurophysiol. 2015 Oct;126(10):1934-40. doi: 10.1016/j.clinph.2014.12.006. Epub 2014 Dec 15.

Abstract

OBJECTIVE

Interhemispheric inhibition (IHI) is typically examined via responses elicited in intrinsic hand muscles. As the cortical representations of proximal and distal muscles in the upper limb are distinguished in terms of their inter-hemispheric projections, we sought to determine whether the IHI parameters established for the hand apply more generally.

METHODS

We investigated IHI at 5 different conditioning stimulus (CS) intensities and a range of short-latency inter-stimulus intervals (ISIs) in healthy participants. Conditioning and test stimuli were delivered over the M1 representation of the right and left flexor carpi radialis respectively.

RESULTS

IHI increased as a function of CS intensity, and was present for ISIs between 7 and 15ms. Inhibition was most pronounced for the 10ms ISI at all CS intensities.

CONCLUSIONS

The range of parameters for which IHI is elicited in projections to the forearm is similar to that reported for the hand. The specific utility lies in delineation of stimulus parameters that permit both potentiation and attenuation of IHI to be assessed.

SIGNIFICANCE

In light of evidence that there is a greater density of callosal projections between cortical areas that represent proximal muscles than between those corresponding to distal limb muscles, and in view of the assumption that variations in functional connectivity to which such differences give rise may have important implications for motor behavior, it is critical to determine whether processes mediating the expression of IHI depend on the effector that is studied. This issue is of further broad significance given the practical utility of movements generated by muscles proximal to the wrist in the context of upper limb rehabilitation.

摘要

目的

通常通过手部固有肌引发的反应来检查半球间抑制(IHI)。由于上肢近端和远端肌肉的皮质表征在半球间投射方面有所不同,我们试图确定为手部建立的IHI参数是否更具普遍性。

方法

我们在健康参与者中,以5种不同的条件刺激(CS)强度和一系列短潜伏期刺激间隔(ISI)研究了IHI。条件刺激和测试刺激分别在右侧和左侧桡侧腕屈肌的M1代表区施加。

结果

IHI随CS强度增加而增加,并且在ISI为7至15毫秒时存在。在所有CS强度下,10毫秒的ISI时抑制最为明显。

结论

在前臂投射中引发IHI的参数范围与手部报道的相似。其具体效用在于描绘允许评估IHI增强和减弱的刺激参数。

意义

鉴于有证据表明,代表近端肌肉的皮质区域之间的胼胝体投射密度大于对应于远端肢体肌肉的皮质区域之间的密度,并且鉴于这种差异引起的功能连接变化可能对运动行为具有重要影响,确定介导IHI表达的过程是否取决于所研究的效应器至关重要。鉴于手腕近端肌肉产生的运动在上肢康复中的实际效用,这个问题具有更广泛的意义。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验