同寡聚体中的对称破缺：巨型血蓝蛋白的奇异案例。

Symmetry breaking in homo-oligomers: the curious case of mega-hemocyanin.

机构信息

Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.

出版信息

Structure. 2015 Jan 6;23(1):3-5. doi: 10.1016/j.str.2014.12.006.

DOI:10.1016/j.str.2014.12.006

Abstract

Mega-hemocyanin is a 13.5 MDa oxygen transporter found in snails. It is built from three stacked rings involving ten subunits each. The cryo-EM structure of the complex presented by Gatsogiannis and colleagues in this issue of Structure revealed an unexpected breaking of 5-fold symmetry in the central ring and a nonequivalent packing of the subunits.

摘要

巨血蓝蛋白是一种 13.5 MDa 的氧载体，存在于蜗牛中。它由三个堆叠的环组成，每个环涉及十个亚基。Gatsogiannis 及其同事在本期《结构》杂志上展示的该复合物的低温电镜结构揭示了中心环中 5 重对称的意外破坏和亚基的不等价包装。