Vale Nuno, Aguiar Luísa, Gomes Paula
Department of Chemistry and Biochemistry, Faculty of Sciences, Centro de Investigação em Química, University of Porto Porto, Portugal.
Front Pharmacol. 2014 Dec 19;5:275. doi: 10.3389/fphar.2014.00275. eCollection 2014.
A range of antimicrobial peptides (AMP) exhibit activity on malaria parasites, Plasmodium spp., in their blood or mosquito stages, or both. These peptides include a diverse array of both natural and synthetic molecules varying greatly in size, charge, hydrophobicity, and secondary structure features. Along with an overview of relevant literature reports regarding AMP that display antiplasmodial activity, this review makes a few considerations about those molecules as a potential new class of antimalarial drugs.
一系列抗菌肽（AMP）在疟原虫的血液阶段或蚊子阶段，或在这两个阶段均对疟原虫（疟原虫属）表现出活性。这些肽包括各种各样的天然和合成分子，它们在大小、电荷、疏水性和二级结构特征方面差异很大。除了概述显示抗疟活性的抗菌肽的相关文献报道外，本综述还对这些分子作为一类潜在的新型抗疟药物进行了一些思考。
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