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用指数弹簧模拟计算绕组细丝模型以代表肌联蛋白。

Simulation of a computational winding filament model with an exponential spring to represent titin.

作者信息

LeMoyne Robert, Petak Jeremy, Tester John, Nishikawa Kiisa

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:836-9. doi: 10.1109/EMBC.2014.6943721.

Abstract

The goal of developing high fidelity simulation of muscle force is of considerable interest for the biomedical community. Traditionally Hill models have been incorporated. However, feasible scope of the Hill model is inherently limited, especially in light of the growing relevance of muscle history dependence. History dependence is considered to be significant for motor control and stability. Attempts have been made to augment the Hill model to emulate history dependence. The titin winding filament model best elucidates history dependence of muscle force including force enhancement. The recent version of the titin winding filament model accounts for the functionality of titin through a pulley linked with the contractile element and a linear spring to represent the elastic properties of titin. A new and more realistic amendment to the winding filament model is incorporation of an exponential spring to characterize the elastic properties of titin. A sensitivity study as a function of the titin exponential spring constant is presented. Overall the amalgamation of the titin exponential spring to the winding filament model improves the respective force enhancement characteristics with a relatively more optimal exponential spring constant that provides a maximal averaged coefficient of determination.

摘要

开发肌肉力量的高保真模拟对生物医学界具有相当大的吸引力。传统上采用的是希尔模型。然而,希尔模型的可行范围本质上是有限的,特别是考虑到肌肉历史依赖性的相关性日益增加。历史依赖性被认为对运动控制和稳定性很重要。人们已尝试扩充希尔模型以模拟历史依赖性。肌联蛋白缠绕细丝模型最能阐明肌肉力量的历史依赖性,包括力量增强。肌联蛋白缠绕细丝模型的最新版本通过与收缩元件相连的滑轮和代表肌联蛋白弹性特性的线性弹簧来解释肌联蛋白的功能。对缠绕细丝模型的一项新的、更现实的修正,是纳入一个指数弹簧来表征肌联蛋白的弹性特性。本文给出了一项作为肌联蛋白指数弹簧常数函数的敏感性研究。总体而言,将肌联蛋白指数弹簧与缠绕细丝模型相结合,以相对更优的指数弹簧常数改善了各自的力量增强特性,并提供了最大的平均决定系数。

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