Yang Fan, Yang Tai-zhu, Luo Hong, Tian Tian, Wang Jing-xin, Chen Da-peng
Department of Diagnostic Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 Nov;45(6):964-9.
To investigate the role of contrast-enhanced ultrasonography (CEUS) with pulsed inversion harmonic imaging in the evaluation of angiogenesis in ovarian tumors.
Forty-two patients of ovarian tumor received CEUS examination, in which the rise time (RT), peak intensity (PI), area under the curve (AUC), time from peak to one half (TTH) and time to peak (TTP) of ovarian tumors were measured. The post- surgical specimens of ovarian tumors were analysed by the stain with polyclonal antibodies against vascular endothelial growth factor (VEGF) and CD34. Correlations between the index of VEGF, microvessel density (MVD) and ultrasonic perfusion parameters were studied.
MVD and VEGF index of ovarian tumors were significantly correlated with CEUS perfusion parameters including PI, AUC and TTH. The correlation coefficients of MVD with PI, AUC and TTH were 0. 569, 0. 623 and 0. 585 respectively; and the correlation coefficients of VEGF with PI, AUG and TTH were 0. 516,0. 640 and 0. 591 respectively. There were significant differences of the perfusion parameters between high and low MVD group.
The perfusion parameters PI, AUC and TTH in CEUS were correlated with MVD and VEGF in ovarian tumors, which may be useful in the evaluation of tumors angiogenesis.
探讨脉冲反转谐波成像的超声造影（CEUS）在评估卵巢肿瘤血管生成中的作用。
42例卵巢肿瘤患者接受CEUS检查，测量卵巢肿瘤的上升时间（RT）、峰值强度（PI）、曲线下面积（AUC）、峰值至一半时间（TTH）和达峰时间（TTP）。用抗血管内皮生长因子（VEGF）和CD34的多克隆抗体对卵巢肿瘤手术标本进行染色分析。研究VEGF指数、微血管密度（MVD）与超声灌注参数之间的相关性。
卵巢肿瘤的MVD和VEGF指数与CEUS灌注参数PI、AUC和TTH显著相关。MVD与PI、AUC和TTH的相关系数分别为0.569、0.623和0.585；VEGF与PI、AUG和TTH的相关系数分别为0.516、0.640和0.591。高MVD组和低MVD组的灌注参数有显著差异。
CEUS中的灌注参数PI、AUC和TTH与卵巢肿瘤中的MVD和VEGF相关，这可能有助于评估肿瘤血管生成。
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