TET2 缺失，拯救 JAK2V617F 造血干细胞。

TET2 loss, a rescue of JAK2V617F HSCs.

机构信息

INSTITUT DE CANCÉROLOGIE GUSTAVE ROUSSY.

出版信息

Blood. 2015 Jan 8;125(2):212-3. doi: 10.1182/blood-2014-10-606624.

DOI:10.1182/blood-2014-10-606624

Abstract

In this issue of Blood, Chen et al and Kameda et al demonstrate that Tet2 loss has 2 effects in Jak2V617F mice: it increases both the severity of the myeloproliferative disorders and the self-renewal properties of the Jak2V617F hematopoietic stem cells (HSCs).

摘要

在本期《Blood》中，Chen 等人和 Kameda 等人表明，Tet2 缺失在 Jak2V617F 小鼠中具有 2 种作用：它增加了骨髓增殖性疾病的严重程度和 Jak2V617F 造血干细胞（HSCs）的自我更新特性。